Antimalarial assessment of certain 1,2,4-Triazoles and Benzoquinolones against Plasmodium knowlesi A1H1

Nurul Syafiqah Rezali

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Type :	article
Subject :	RC Internal medicine
Main Author :	Nurul Syafiqah Rezali
Additional Authors :	Nurul Afiqah Zahrin Amatul Hamizah Ali Ng Yee Ling Hani Kartini Agustar Lau Yee Ling
Title :	Antimalarial assessment of certain 1,2,4-Triazoles and Benzoquinolones against Plasmodium knowlesi A1H1

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2023
Corporate Name :	Universiti Pendidikan Sultan Idris

Abstract : Universiti Pendidikan Sultan Idris

Previous studies have reported the use of nitrogen-heterocyclic compounds to treat malaria. Interestingly, quinolone and 1,2,4-triazole scaffolds demonstrated an outstanding capacity to target at least two stages of the malaria parasite life cycle, especially when they are hybrid with other nitrogen heterocycles. Thus, the objective of this study is to assess the drug susceptibility of Plasmodium knowlesi A1H1 parasites to certain 1,2,4-triazoles and benzoquinones that bear pyrrolidinones using a plasmodium lactate dehydrogenase assay. All synthesized compounds showed moderate activity against P. knowlesi A1H1 with EC50 values in the range of 13.39-28.85 μM. Both 1,2,4-triazoles and quinolone derivatives were synthesized using commercially available pyrrolidinones. Keywords: 1,2,4-Triazoles; quinolones; antimalarial, Plasmodium knowlesi A1H1

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