Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity

Ahmed Kareem Obaid Aldulaimi

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Type :	article
Subject :	Q Science (General)
Main Author :	Ahmed Kareem Obaid Aldulaimi
Additional Authors :	Saripah Salbiah Syed Abdul Azziza Yuhanis Mhd Bakri Mohd Azlan Nafiah Saadon Abdulla Aowda Khalijah Awang Marc Litaudon
Title :	Two New isoquinoline alkaloids from the bark of Alphonsea cylindrica King and their antioxidant activity

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2019
Corporate Name :	Universiti Pendidikan Sultan Idris

Abstract : Universiti Pendidikan Sultan Idris

Two new isoquinoline alkaloids, iraqiine (1) and kareemine (2), along with five known alkaloids, muniranine (3), kinabaline (4), O-methylmoschatoline (5), atherospermidine (6) and N-methylouregidione (7), were purified from the dichloromethane crude extract of Alphonsea cylindrica bark. The structures of these compounds were elucidated through extensive 1D and 2D NMR, IR and LC–MS studies and comparison with previously reported data. Compounds (1–5 and 7) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1, 3 and 4 showed the highest antioxidant activities with IC50 values of 48.77 ± 1.01, 44.51 ± 1.12 and 64.28 ± 0.93 μg/ml, respectively

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