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Type :article
Subject :Q Science (General)
Main Author :Wan Mohd Nuzul Hakimi Wan Salleh
Additional Authors :Nur Athirah Hashim
Farediah Ahmad
Shamsul Khamis
Title :A new amide from piper maingayi Hk.F. (Piperaceae)
Place of Production :Tanjong Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2019
Corporate Name :Universiti Pendidikan Sultan Idris
PDF Guest :Click to view PDF file

Abstract : Universiti Pendidikan Sultan Idris
Phytochemical investigation from the leaves and stem extracts of Piper maingayi Hk.F. resulted in the isolation of a new amide,N-isobutyl-15-(3??,4??-methylenedioxyphenyl)-2E,4E,12Z-pentadecatrienamide (1), together with sesamin (2), piperumbellactam A (3), cepharadione A (4), cepharadione B (5), piperolactam A (6), oleic acid (7), methyl linolenate (8), β-sitosterol (9), butyl dodecanoate (10), and isovanillic acid (11). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. Compound (1) exhibited strong inhibition against lipoxygenase (15-LOX) at IC50 42.5 μM and antibacterial activity toward Bacillus subtillis and Pseudomas aeruginosa with minimum inhibitory concentration (MIC) value of 250 μg/mL each.  


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