|
UPSI Digital Repository (UDRep)
|
|
| ||||||||||||||||||||||
| Abstract : Universiti Pendidikan Sultan Idris |
| Phytochemical investigation from the leaves and stem extracts of Piper maingayi Hk.F. resulted in the isolation of a new amide,N-isobutyl-15-(3??,4??-methylenedioxyphenyl)-2E,4E,12Z-pentadecatrienamide (1), together with sesamin (2), piperumbellactam A (3), cepharadione A (4), cepharadione B (5), piperolactam A (6), oleic acid (7), methyl linolenate (8), β-sitosterol (9), butyl dodecanoate (10), and isovanillic acid (11). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. Compound (1) exhibited strong inhibition against lipoxygenase (15-LOX) at IC50 42.5 μM and antibacterial activity toward Bacillus subtillis and Pseudomas aeruginosa with minimum inhibitory concentration (MIC) value of 250 μg/mL each.
|
| References |
1. Jaramillo MA, Manos PS, Paul SM. Phylogeny and patterns of floral diversity in the genus Piper (Piperaceae). Am J Bot. 2001;88(4):706-716. 2. Quijano-Abril MA, Callejas-Posada R, Miranda-Esquivel DR, Rafael D, Miranda E. Areas of endemism and distribution patterns for Neotropical Piper species (Piperaceae). J Biogeogr. 2006;33(7):1266-1278. 3. Parmar VS, Jain SC, Bisht KS, et al. Phytochemistry of the genus Piper. Phytochemistry. 1997;46(4):597-673. 4. Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytother Res. 2013;27(8):1121-1130. 5. Gupta M, Gupta A, Gupta S. In vitro antimicrobial and phytochemical analysis of dichloromethane extracts of Piper nigrum (black pepper). Orient J Chem. 2013;29(2):777-782. 6. Marques JV, Kitamura ROS, Lago JHG, Young MCM, Guimarães EF, Kato MJ. Antifungal amides from Piper scutifolium and Piper hoffmanseggianum. J Nat Prod. 2007;70(12):2036-2039. 7. Rukachaisirikul T, Siriwattanakit P, Sukcharoenphol K, et al. Chemical constituents and bioactivity of Piper sarmentosum. J Ethnopharmacol. 2004;93(2-3):173-176. 8. Sunila ES, Kuttan G. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J Ethnopharmacol. 2004;90(2-3):339-346. 9. Muharini R, Liu Z, Lin W, Proksch P. New amides from the fruits of Piper retrofractum. Tetrahedron Lett. 2015;56(19):2521-2525. 10. Sirat HM, Thai OB, Ahmad F. Chemical composition of the essential oil of Piper maingayi Hk. F. J Essent Oil Res. 2010;22(4):323-324. 11. Hashim NA, Ahmad F, Susanti D. Antioxidant and antityrosinase activities of Piper maingayi Hk. essential oils. J Teknol. 2016;78(1):169-174 12. Ahmad F, Jamil S, Ibrahim AZ, Read RW. Alkenylamides from Piper maingayi Hk. F. Pertanika J Sci Technol. 1996;4:167-171. 13. Ahmad F, Jamil S, Read RW. Isobutylamides from Piper ridleyi. Phytochemistry. 1995;40(4):1163-1165. 14. Salleh WMNHW, Ahmad F, Khong HY, Sirat HM. Chemical compositions, antioxidant and antimicrobial activity of the essential oils of Piper officinarum (Piperaceae. Nat Prod Commun. 2012;7(12):1659-1662. 15. Salleh WMNHW, Ahmad F, Khong HY. Chemical compositions and antimicrobial activity of the essential oils of Piper abbreviatum, P. erecticaule and P. lanatum (Piperaceae). Nat Prod Commun. 2014;9(12):1795-1798. 16. Salleh WMNHW, Ahmad F, Khong HY, Zulkifli RM. Chemical compositions and biological activities of essential oils of Beilschmiedia glabra. Nat Prod Commun. 2015;10(7):1297-1300.
|
| This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials. You may use the digitized material for private study, scholarship, or research. |