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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Background: Diabetes mellitus is a metabolic diseases characterized by disordered metabolism and abnormally high levels of blood glucose. Aim: This study was conducted to study the effects of Areca catechu seeds and Ficus deltoidea fruits methanolic extracts on glycemic and reproductive parameters of alloxan-induced diabetic rats.
Methodology: Diabetes mellitus was induced by a single intraperitoneal injection of 100 mg/kg bwt alloxan monohydrate. Blood glucose level was estimated using electronic glucometer and sperm parameters were measured using Makler chamber. Insulin and testosterone were estimated by ELISA kits.
Results: A. catechu and F. deltoidea methanolic extracts significantly reduced blood glucose levels and increased insulin secretion. Both extracts also significantly increased sperm quality and testosterone secretion in diabetic rats.
Conclusion: Present study demonstrated anti-hyperglycemic and pro-fertility effects of A. catechu and F. deltoidea methanolic extracts in diabetic rats. Further studies are currently undergoing to determine their mechanisms and mode of action that decreases the blood glucose levels and increases the sperm quality in diabetic rats. |
| References |
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