Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

Hanita Omar

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Type :	article
Subject :	Q Science (General)
Main Author :	Hanita Omar
Additional Authors :	Mehran Fadaeinasab Hairin Tahad Aty Widyawaruyantie Mohd Azlan Nafiah Tiah Rachmatiah
Title :	Aporphine alkaloids with in vitro antiplasmodial activity from the leaves of Phoebe tavoyana

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2020
Corporate Name :	Universiti Pendidikan Sultan Idris
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Abstract : Universiti Pendidikan Sultan Idris

One new aporphine named tavoyanine A (1), along with four known aporphines laetanine (2), roemerine (3), laurolitsine (4), and boldine (5), and one morphinandienone type sebiferine (6) were isolated from the leaves of Phoebe tavoyana (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (3), laurolitsine (4), boldine (5), and sebiferine (6). The results showed that 3–6 have a potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with IC50 values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively.

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