UPSI Digital Repository (UDRep)
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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Lead is a multisystemic toxicant when it accumulates and is hazardous to health. This study was conducted to determine the effect of Caulerpa lentillifera aqueous extract on lead accumulation in the internal organs and liver functions of lead-intoxicated rats. Sprague Dawley rats (n = 24) were divided into four groups (n = 6). Group I was healthy rats treated with saline (2 ml/kg bwt) daily for 28 days. Group II was healthy rats treated with C. lentillifera aqueous extract (500 mg/kg bwt) daily for 28 days. Group III was intoxicated with lead acetate (20 mg/kg bwt) daily for 4 days and then treated with saline (2 ml/kg bwt) for another 24 days. Group IV was intoxicated with lead acetate (20 mg/kg bwt) daily for 4 days and then treated with C. lentillifera aqueous extract (500 mg/kg bwt) for another 24 days. Lead accumulation in the internal organs was measured by the atomic absorption spectrophotometer and the liver function markers were determined using assay kits. Lead intoxication significantly (p < 0.05) increased lead accumulation in the rats’ internal organs and affected their liver functions. C. lentillifera aqueous extract supplementation to leadintoxicated rats significantly (p < 0.05) decreased lead accumulation in the rats’ internal organs and protected their liver functions. This study concludes that C. lentillifera aqueous extract possesses the capability of a chelating agent and attenuates the effect of lead on lead-intoxicated rats |
| References |
Adikwu E, Deo O, Geoffrey OP, Enimeya DA. Lead organ and tissue toxicity: roles of mitigating agents (Part I). Br J Pharmacol Toxicol, 2013; 4:232-240. Alwaleedi SA. Hematobiochemical changes induced by lead intoxication in male and female albino mice. Natl J Physiol Pharm Pharmacol, 2016; 6:46–51. Badiei K, Mostaghni K, Nowrooziasl A, Naeini AT. Ameliorated effects of Allium sativum on subclinical lead toxicity in goats. Pak Vet J, 2006; 26:184–6. Damstra T. Toxicological properties of lead. Environ Health Perspect, 1977; 19:297–307. Daud D, Arsad NFM, Ismail A, Tawang A. Anti-pyretic action of Caulerpa lentillifera, Hibiscus rosa-sinensis and Piper sarmentosum aqueous extract in mice. Asian J Pharm Clin Res, 2016; 9:145–7. Daud D, Nawi NM, Ismail A, Tawang A. The effect of Eucheuma cottonii on sperm quality and tissue lead levels in rats exposed to lead nitrate. Biotechnol Indian J, 2015; 11:138–43. Flora G, Gupta D, Tiwari A. Toxicity of lead: a review with recent updates. Interdiscip Toxicol, 2012; 5:47–58. Garcia MTA, Gonzalez ELM. Toxic effects of perinatal lead exposure on the brains of rats; Involvement of oxidative stress and the beneficial role of antioxidants. Food Chem Toxicol, 2008; 46:2089–95. Heidarian E, Rafieian-Kopaei, M. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol, 2013; 51:1104–9. Ibrahim NM, Eweis EA, El-Beltagi HS, Abdel-Mobdy YE. Effect of lead acetate toxicity on experimental male albino rat. Asian Pac J Trop Biomed, 2012; 2(1):41–6. Kilikdar D, Mukherjee D, Mitra E, Ghosh AK, Basu A, Chandra AM, Bandyoapdhyay D. Protective effect of aqueous garlic extract against lead-induced hepatic injury in rats. Indian J Exp Biol, 2011; 49:498–510. Matanjun P, Mohamed S, Mustapha NM, Muhammad K. Nutrient content of tropical edible seaweeds, Caulerpa lentillifera and Sargassum polycystum. J Appl Phycol, 2009; 21:75–80. Nguyen VT, Jinn-Pying U, Guo-Jane T. Proximate composition, total phenolic content and antioxidant activity of seagrape (Caulerpa lentillifera). J Food Sci, 2011; 76:950–8. Offor SJ, Mbagwu HOC, Orisakwe OE. Lead induced hepatorenal damage in male albino rats and effects of activated charcoal. Front Pharmacol, 2017; 8:1–10. Perron NR, Brumaghim JL. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys, 2009; 53:75–100. Seddik I, Bah TM, Aoues A, Brnderdour M, Silmani M. Dried leaf extract protects against lead-induced neurotoxicity in Wistar rats. Eur J Sci Res, 2010; 42(1):139–51. Sharma BR, Rhyu DY. Anti-diabetic effects of Caulerpa lentillifera: stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes. Asian Pac J Trop Med, 2014; 4:575–80. Sharma V, Kansal L, Sharma A, Lodi S, Sharma SH. Ameliorating effect of Coriandrum sativum extracts on haematological and immunological variables in an animal model of lead intoxication. J Pharm Allied Health Sci, 2011; 1:16–29. Sun H, Wang N, Nie X, Zhao L, Li Q, Cang Z, Chen C, Lu M, Cheng J, Zhai H, Xia F, Ye L, Lu Y. Lead exposure induces weight gain in adult rats, accompanied by DNA hypermethylation. PloS One, 2017; 12:e0169958. Thenmozhi M, Dhanalakshmi M, Manjula-Devi K, Sushila K, Thenmozhi S. Evaluation of hepatoprotective activity of Leucas aspera hydroalcoholic leaf extract during exposure to lead acetate in male albino Wistar rats. Asian J Pharm Clin Res, 2013; 6:78–81.
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