UPSI Digital Repository (UDRep)
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Abstract : Universiti Pendidikan Sultan Idris |
This study aimed to investigate the properties of aphrodisiac and to evaluate the
toxicological effect of leaves aqueous extract from Aquilaria malaccensis (AEAM)
and Aquilaria subintegra (AEAS) against ICR mice. The aphrodisiac properties,
which include sexual behaviour, orientation activity, number of offspring, male to
female ratio of offspring, the percentage of pregnancy and testosterone level.
Meanwhile, toxicological evaluation consists of acute and sub-acute study. In
aphrodisiac study, the treated groups received 50, 100, 200, 500, and 1000 mg/kg
body weight (b.w.) of extracts for 21 consecutive days. In acute toxicity study, the
treated animals received a single dose at 2000 mg/kg b.w., while in sub-acute toxicity
study, the treated groups received 50, 100, 150, 200, 500, and 1000 mg/kg b.w. of
extracts for 21 consecutive days compared to control groups that received normal
saline only. Statistical analyses were performed using t-test and one-way ANOVA
and also considered significantly different at p0.05) in sexual behaviour and orientation activity of treated mice as
compared to the controls. The treatment groups that received higher doses (500 and
1000 mg/kg) of both extracts found to be inactive due to the sedative effect. However,
higher aphrodisiac properties were displayed by AEAM treated mice compared to
AEAS. The number of offspring in AEAS was higher compared to AEAM.
Toxicological evaluation showed that there was a significant increase (p |
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