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Type :thesis
Subject :RA Public aspects of medicine
Main Author :Fayyadh, Aws Ali
Title :Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
Place of Production :Tanjong Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2019
Corporate Name :Universiti Pendidikan Sultan Idris
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Abstract : Universiti Pendidikan Sultan Idris
Alternative treatments of insulin-independent diabetes mellitus have attracted many researchers over the years. The treatment should have a clearer mechanism of action and easier to administer. Asian traditional medicine contains a number of herbal extracts believed to combat the symptoms of diabetes mellitus. Thus, the purpose of this study was to investigate the potential of agarwood leaf extracts against type II diabetic ICR mice. A group of ICR mice of both sexes, aged 8 weeks were induced by a single intraperitoneal injection of 100 mg/kg body weight of streptozotocin (STZ). Mice (fasting) with blood glucose over 200 mg/dl were used in this experiment. Diabetic mice were divided into three groups and were forced fed with 50, 100 and 150 mg plant extract /kg body weight for 14 consecutive days respectivly. Two different types of solvents used in this study were distilled water and 95% methanol. Aqueous and methanolic extracts of Aquilaria malaccensis leaf exhibited a significant reduction of hyperglycemia in fasting diabetic mice at the lowest concentration (50 mg/kg b.w). Both extracts with different solvents reduced hyperglycemia within three days of administration and these were observed for all doses. For methanolic extract, low (50 mg/kg body weight) and moderate (100 mg/kg body weight) doses, reduced hyperglycemia in fasting diabetic mice compered with the highest dose (150 mg/kg body weight) after two hours of forced fed. In conclusion, these data suggest that both extracts of agarwood leaf possess potential anti-diabetic activity in both diabetic male and female mice. Hence, active constituents of agarwood leaf extracts which responsible for antidiabetic activity requires further to be investigated and these findings contribute to potential diabetic treatment.


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