UPSI Digital Repository (UDRep)
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Abstract : Universiti Pendidikan Sultan Idris |
Alternative treatments of insulin-independent diabetes mellitus have attracted many researchers
over the years. The treatment should have a clearer mechanism of action and easier to administer.
Asian traditional medicine contains a number of herbal extracts believed to combat the
symptoms of diabetes mellitus. Thus, the purpose of this study was to investigate the potential
of agarwood leaf extracts against type II diabetic ICR mice. A group of ICR mice of both sexes,
aged 8 weeks were induced by a single intraperitoneal injection of 100 mg/kg body weight of
streptozotocin (STZ). Mice (fasting) with blood glucose over 200 mg/dl were used in this
experiment. Diabetic mice were divided into three groups and were forced fed with 50, 100 and
150 mg plant extract /kg body weight for 14 consecutive days respectivly. Two different types
of solvents used in this study were distilled water and 95% methanol. Aqueous and methanolic
extracts of Aquilaria malaccensis leaf exhibited a significant reduction of hyperglycemia in
fasting diabetic mice at the lowest concentration (50 mg/kg b.w). Both extracts with different
solvents reduced hyperglycemia within three days of administration and these were observed for
all doses. For methanolic extract, low (50 mg/kg body weight) and moderate (100 mg/kg body
weight) doses, reduced hyperglycemia in fasting diabetic mice compered with the highest dose
(150 mg/kg body weight) after two hours of forced fed. In conclusion, these data suggest that
both extracts of agarwood leaf possess potential anti-diabetic activity in both diabetic male and
female mice. Hence, active constituents of agarwood leaf extracts which responsible for antidiabetic
activity requires further to be investigated and these findings contribute to potential
diabetic treatment. |
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