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Type :article
Subject :R Medicine
ISSN :17732247
Main Author :Al-Obaidi, Jameel R.
Title :An in vitro cytotoxicity of a novel pH-sensitive lectin loaded-cockle shell-derived calcium carbonate nanoparticles against MCF-7 breast tumour cell
Place of Production :Tanjung Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2021
Notes :Journal of Drug Delivery Science and Technology
Corporate Name :Universiti Pendidikan Sultan Idris
HTTP Link :Click to view web link

Abstract : Universiti Pendidikan Sultan Idris
The acidic microenvironment of tumour cells requires a pH-sensitive delivery mechanism for improving drug release. In this study, we investigated the feasibility of using pH-sensitive ACC nanoparticles with sustained-release performance and slow degradability as carriers for lectins isolated from edible mushroom Agaricus bisporus (ABL) that exhibited anti-proliferating effects on tumour cells. ABL was purified and characterized using ion-exchange, gel filtration chromatography, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry. ABL-ACC nanoparticles were synthesized through a simple precipitation process coupled with mechanical grinding. The conjugated ABL-ACC-NPs were characterized using Fourier-transform infrared spectroscopy, X-ray powder diffraction, scanning electron microscope, transmission electron microscope and zeta potential. Cytotoxicity of ABL-ACC-NPs was analyzed using methylthiazol tetrazolium assay against MCF-7 cells compared with ABL and ACC-NPs. The results indicated biostability of ACC-NPs and low toxicity toward MCF-7 cells, and induced increased reduction in MCF-7 viability compared with ABL. ABL-ACC-NPs-FITC showed fully internalization and accumulation inside the nucleus comparing with ABL-FITC which showed only accumulation around the nuclear envelope. Inclusively, conjugation of ABL with ACC-NPs has improved its cytotoxicity, enhanced its bioavailability, internalization into the tumour cells, accumulation in cell organelles which may promote cell responses and subsequently triggered cell death. ? 2020 Elsevier B.V.

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