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Type :article
Subject :QD Chemistry
ISSN :10113924
Main Author :Wan Mohd Nuzul Hakimi Wan Salleh
Additional Authors :Mohd Azlan Nafiah
Title :Chemical constituents and acetylcholinesterase inhibitory activity of beilschmiedia insignis gamble
Place of Production :Tanjung Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2021
Notes :Bulletin of the Chemical Society of Ethiopia
Corporate Name :Universiti Pendidikan Sultan Idris
Web Link :Click to view web link
PDF Full Text :Login required to access this item.

Abstract : Universiti Pendidikan Sultan Idris
Secondary metabolites from natural products are potential sources of acetylcholinesterase inhibitors, which are key enzymes in the treatment of many neurodegenerative diseases. Inspired by the reported activities of alkaloids herein we report the chemical investigation on the chemical constituents from Beilschmiedia insignis and their acetylcholinesterase inhibitory activity. Isolation of the stem bark of B. insignis led to the isolation and identification of five aporphine alkaloids, namely isocorydine (1), norisocorydine (2), (+)-laurotetanine (3), (+)- N-methyllaurotetanine (4), and (+)-boldine (5), together with ?-sitosterol (6), ?-sitostenone (7), lupeol (8), and lupenone (9). The chemical structures of these compounds were obtained by analysis of their spectroscopic data, as well as the comparison with that of reported data. Acetylcholinesterase inhibitory activity revealed that all isolated alkaloids were found to inhibit AChE with percentage inhibition values ranged from 44.9 to 74.5%. This is the first report on phytochemicals from B. insignis. 2021 Chemical Society of Ethiopia and The Authors


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