Synthesis of Indolostilbenes via FeCl3-promoted Oxidative Cyclisation and their Biological Effects on NG108-15 Cell Viability and H2O2-induced Cytotoxicity

Mohamad Nurul Azmi

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Type :	article
Subject :	Q Science (General)
ISSN :	1675-3402
Main Author :	Mohamad Nurul Azmi
Additional Authors :	Mohd Azlan Nafiah
Title :	Synthesis of Indolostilbenes via FeCl3-promoted Oxidative Cyclisation and their Biological Effects on NG108-15 Cell Viability and H2O2-induced Cytotoxicity

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2021
Notes :	Journal of Physical Science
Corporate Name :	Universiti Pendidikan Sultan Idris
Web Link :	Click to view web link
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Abstract : Universiti Pendidikan Sultan Idris

A convenient and simple radical cation cyclisation of 3,5-dimethoxystilbene was developed using the commercially available FeCl3under mild condition. It enabled the construction of a new class of indolostilbenes (i.e., indole-stilbene hybrid). Various parameters were investigated to obtain better yields (more than 42%) compared with the previously reported. The synthesised indolostilbenes were characterised, and their mechanism of formation was discussed. The synthesised compounds were submitted for biological assay on NG108-15 cell viability and H2O2-induced cytotoxicity. The result showed that two indolostilbenes have promising protective activity against H2O2. ? Penerbit Universiti Sains Malaysia, 2021. This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).

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