Computer Numerical Control (CNC) systems are moving toward adopting the STEP-NC data interface model as their future standard. It has been developed for use in subtractive manufacturing with great success, but its use in additive manufacturing is still in the research and development stage. The incorporation of STEP-NC into the CNC system is still an open and present challenge. This article presents a method for making use of the STEP-NC data interface model for 3D printing. The method makes use of the CAD data of either the ISO10303 or ISO 14649 data interface model in part 21 of the physical file representation. A system is being developed to generate the tool paths necessary for 3D printing from STEP-NC part 21. It has been carried out on a 3D printer through the utilization of indirect and interpreted STEP-NC programming techniques. In order to carry out 3D printing operations, the system makes use of tools that are based on virtual component technology and are controlled by a part.....

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The Coronavirus disease 2019, or COVID-19, has shifted the medical paradigm from face-to-face to telehealth. Telehealth has become a vital resource to contain the virus spread and ensure the continued care of patients. In terms of preventing cardiovascular diseases, automating electrocardiogram (ECG) classification is a promising telehealth intervention. The healthcare service ensures that patient care is appropriate, comfortable, and accessible. Convolutional neural networks (CNNs) have demonstrated promising results in ECG categorization, which require high accuracy and short training time to ensure healthcare quality. This study proposes a one-dimensional-CNN (1D-CNN) arrhythmia classification based on the differential evolution (DE) algorithm to optimize the accuracy of ECG classification and training time. The performance of 1D-CNNs of different activation functions are optimized based on the standard DE algorithm. Finally, based on MIT-BIH and SCDH arrhythmia databases, the perfo.....

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Malignant transformations are dependent on an aberrant increase in tubulin and microtubule activities for cancer cell growth, migration, invasion and metastasis. The present work includes design and synthesis of a new series of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors. These derivatives harness lipophilicity, ease of synthesis and antiproliferative activity of lipidated 1,3-diaryl propenones and their cyclized derivatives. New compounds were synthesized from 4?-hydroxyacetophenone via O-alkylation, condensation with different aromatic aldehydes followed by cyclization with urea, thiourea or guanidine. Cyclization of 1,3-diaryl propenones into 4,6-diaryl pyrimidines increased their antiproliferative activity with the most potent derivative 19 achieving IC50 values at low micro molar concentration against two human cancer cell lines; MCF-7 (breast) and HepG-2 (liver). Compound 19 induced S-phase cell cycle arrest and a.....

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Introduction: Cancer is a major issue in medical science with increasing death cases every year worldwide. Therefore, searching for alternatives and nonorthodox methods of treatments with high efficiency, selectivity and less toxicity is the main goal in fighting cancer. Acetyl-11-keto-?-boswellic acid (AKBA), is a derivative pentacyclic triterpenoid that exhibited various biological activities with potential anti-tumoral agents. In this research, AKBA was utilized to examine the potential cytotoxic activity against MCF-7 cells in vitro and monitor the cellular and morphological changes with a prospective impact on apoptosis induction. Methods: The cytotoxic activity of AKBA was measured by 3(4,5dimethylthiazole- 2-yl)-2,5 diphyneltetrazolium bromide (MTT) assay. A dose-dependent inhibition in MCF-7 cell viability was detected. The clonogenicity of MCF-7 cells was significantly suppressed by AKBA increment in comparison with untreated cells. Result: Morphologically, exposure of MCF-7 c.....

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The optical absorption and emission properties of 20Li2O-xBi2O3-(78-x)TeO2-1Er2O3-1Ag glass system had been analyzed to investigate the hypersensitivity shift and its mechanism. According to the Covalent model, the hypersensitive shift indicated by the drop of F2 at x = 5 mol% can be attributed to charge transfer from O2 ligands to Er3+ ions meanwhile according to the Dielectric screening model, drop of F2 may due to Er3+ ions contraction. The dynamic coupling mechanism was used to explain hypersensitivity transition probabilities in non-centrosymmetric systems. The addition of Bi2O3 may modify the site symmetry of Er3+ ions and oxygen to a high asymmetry ?2, resulting in an asymmetrical electron distribution, thus increasing Er-O covalency, as shown by the maximum ?2 value at x = 5 mol%. The Er3+ ions site symmetry was investigated using Hamiltonian crystal field fitting in the frame of the D4 point symmetry model, which yielded maximum crystal field strength Nv at x = 5 mol%, indicat.....

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The iridium(III) complex, Ir(bFppy)2(pyim) (bFppy = 2-(2-butoxy-4-fluorophenyl)pyridine and pyim = 2-(1H-Imidazol-2-yl)pyridine) was excellently prepared between 2-(1H-Imidazol-2-yl)pyridine and chloro-bridged iridium(III) dimer via reflux reaction. Butoxy functional group and fluorine atom were added to the phenyl ring of 2-phenylpyridine at positions 2 and 4 respectively, as cyclometalating ligand. The Ir(bFppy)2(pyim) complex was characterized by spectroscopic methods: FTIR, NMR, LCMS and UVVis absorption. The presence of two sharp peaks at 1256 cm?1 and 1129 cm?1 due to ?(CO) was revealed by IR analysis. The bands appear in the range of 15941567 cm?1 owing to the C[dbnd]C and C[dbnd]N aromatic ring stretching vibrations of phenyl and pyridine. The 1H NMR spectrum showed signals in the range of ? 5.508.60 ppm corresponding to phenylpyridine and pyridylimidazole protons. In contrast, the proton signals in the range of ? 0.804.50 ppm, assignable to butyl substituent. The UVVis spectru.....

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Research on language teaching quality has certainly stood out enough to be noticed as the momentum higher school teaching change proceeds to extend and develop. The way to further developing language teaching quality is to further develop teaching quality, and educator assessment is a significant instrument for doing as such. Accordingly, school administration necessitates the turn of events and refinement of a framework for assessing language teaching quality. Thus, hybrid learning technique for assessing the teaching quality of high school instructors should be created. We present an interesting model for assessing the quality of homeroom teaching involving artificial intelligence innovation in high schools, which depends on better hereditary calculations and neural networks. The fundamental thought is to utilize higher request factual elements (skewness, change, second and kurtosis), even vulnerability, Improved Independent Component Analysis (IICA), Holo-entropy based highlights to.....

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Phylogenetic inference is an important approach that allows the recovery of the evolutionary history and the origin of the Chlorellaceae species. Despite the species potential for biofuel feedstock production, their high phenotypic plasticity and similar morphological structures among the species have muddled the taxonomy and identification of the Chlorellaceae species. This study aimed to decipher Chlorellaceae DNA barcode marker heterogeneity by examining the sequence divergence and genomic properties of 18S rRNA, ITS (ITS1-5.8S rRNA-ITS2-28S rRNA), and rbcL from 655 orthologous sequences of 64 species across 31 genera in the Chlorellaceae family. The study assessed the distinct evolutionary properties of the DNA markers that may have caused the discordance between individual trees in the phylogenetic inference using the Robinson-Foulds distance and the Shimodaira-Hasegawa test. Our findings suggest that using the supermatrix approach improves the congruency between trees by reducing.....

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This research aims to identify the role of family and school environments in predicting emotional intelligence and student well-being. It also examines whether or not emotional intelligence acts as a mediator. A total of 500 senior high school students from 16 private high schools in Pemalang District, Indonesia, completed this survey in the 2020-2021 academic year. Data analysis was carried out using Structural Equation Modeling (SEM) analysis with Partial Least Square (SEM-PLS). The results show that family environment affects the fulfilment of student well-being. Emotional intelligence was not an essential mediator in the relationship between the family environment and student well-being. The school environment also had a decisive role in fulfilling student well-being. Emotional intelligence was an essential mediator between the school environment and student well-being. Student well-being should be realized. It is necessary to address the welfare of teachers in the school environme.....

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In recent years, there has been a notable rise in the utilization of augmented reality within educational settings. However, there is still room for improvement in early childhood education. This study aims to investigate how current augmented reality works in early childhood education between 2017 and 2022 using library research methodology. The study's content was analyzed based on the case studies on integrating augmented reality in early school education between 2017 and 2022. 26 studies were found when the keyword "Augmented Reality in early school" was used to start the study (in primary school). With a sample size of fewer than 21 kids, early literacy discovered that Science (Animals, Newton) was the most frequently used subject. Regarding data collection techniques, testing has emerged as the dominant technique in research of "marker-based" augmented reality on mobile devices. These findings help to clarify the best ways to use this technology in early learning settings. Over t.....

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