UPSI Digital Repository (UDRep)
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Total records found : 77 |
Simplified search suggestions : Wan Mohd Nuzul Hakimi Bin W Salleh |
1 | 2019 article | In Vitro Pharmacological Evaluation of the Leaves and Stem Bark Extracts of Beilschmiedia penangiana Gamble Wan Mohd Nuzul Hakimi Wan Salleh The leaves and stem bark extracts of B. penangiana were screened to evaluate their antioxidant, antimicrobial,tyrosinase, lipoxygenase, and acetylcholinesterase activities. Evaluation of antioxidant activities were tested against DPPH, ABTS, and total phenolic content (TPC) assays. The antimicrobial activity were investigated by microdilution method for determination of MIC, MBC, and MFC. Tyrosinase and lipoxygenase inhibitory activities were analysed using mushroom tyrosinase and lipoxygenase enzymes, respectively. In addition, the acetylcholinesterase activity was tested using cholinesterase enzyme. The methanol extract of stem bark showed the highest phenolic content (176.8 mg GAE/g), DPPH free radical scavenging (IC50 95.5 μg/mL), ABTS (IC50 124.8 μg/mL), and lipoxygenase inhibitory activity (I: 46.3%). All extracts showed from moderate to weak activity with MIC/MBC/MFC values in the ranged of 62.5-1000 µg/mL. The ethyl acetate stem bark extract revealed the highest percentage i..... 14388 hits |
2 | 2017 article | Phytochemistry and biological activities of the genus Ocotea (Lauraceae) : a review on recent research results (2000-2016) Wan Salleh Wan Mohd Nuzul Hakimi, Ahmad Farediah, 1633 hits |
3 | 2017 article | Phytochemistry and biological activities of the Genus Knema (Myristicaceae) Wan Salleh Wan Mohd Nuzul Hakimi, Ahmad Farediah, 602 hits |
4 | 2017 article | Phytochemicals and biological activities of Macaranga hosei and Macaranga constricta (euphorbiaceae) Wan Salleh Wan Mohd Nuzul Hakimi, Abdul Razak Nur Zawani, Ahmad Farediah, 851 hits |
5 | 2020 article | A new xanthone and a new benzophenone from the roots of Garcinia hombroniana Wan Mohd Nuzul Hakimi Wan Salleh In this study, the roots of Garcinia hombroniana were chemically investigated, in which novel derivatives of xanthone and benzophenone, known as garcihomxanthone (1) and garcihombrianone (2), respectively, together with garceduxanthone (3), cheffouxanthone (4), norathyriol (5), and 2,3′,4,5′-tetrahydroxy-6-methoxybenzophenone (6) were isolated.. The structures of these compounds were elucidated by extensive spectroscopic techniques and evaluated based on references with previous literature data.
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6 | 2020 article | Chemical constituents of Beilschmiedia penangiana Wan Mohd Nuzul Hakimi Wan Salleh As part of our continuing search to explore novel natural compounds from Beilschmiedia species, we have carried out a phytochemical study of the leaves and stem bark extracts of B. penangiana. As a result, four alkaloids, (+)-reticuline (1) [8], (+)-boldine (2) [9], (+)-norboldine (3) [10], and lindcarpine (4) [10] together with five other compounds, β-sitosterol (5) [7], β-sitostenone (6) [7], lupeol (7) [6], lupenone (8) [6], and taraxerol (9) [7], were successfully isolated
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7 | 2021 article | Characterization of volatile components of chassalia chartacea and its acetylcholinesterase inhibitory activity Wan Mohd Nuzul Hakimi Wan Salleh [No abstract available].. 286 hits |
8 | 2017 article | Biflavonoids from the leaves and stem bark of garcinia griffithii and their biological activities Wan Salleh Wan Mohd Nuzul Hakimi, Nik Sazali Nik Shazwani Afifah, Ahmad Farediah, - Muhammad Taher, 3120 hits |
9 | 2019 article | Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum miq Wan Mohd Nuzul Hakimi Wan Salleh Chemical constituents and lipoxygenase inhibitory activity of the aerial part of Piper stylosum have been studied. Fractionation and purification of the extracts afforded five lignans, identified as yangambin (1), sesamin (2), syringaresinol (3), pinoresinol (4), and medioresinol (5), together with other constituents; 4-allyl resorcinol, β-sitosterol, β-sitostenone, taraxerol, vanilin, and vanilic acid. The structures of these compounds were established by analysis of their spectral data, as compared to that of reported compounds. The lipoxygenase inhibitory activity of the extracts and isolated lignans were also evaluated.. 1075 hits |
10 | 2019 article | Chemical composition and anticholinesterase inhibitory activity of the essential oil of Pseuduvaria macrophylla (Oliv.) Merr. from Malaysia Wan Mohd Nuzul Hakimi Wan Salleh This study was designed to examine the chemical composition and anticholinesterase inhibitory activity of the essential oil of Pseuduvaria macrophylla (Oliv.) Merr. (Annonaceae) from Malaysia. The essential oil was obtained by hydrodistillation and fully analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The analysis led to the identification of thirty-four chemical components that represented 87.7 ± 0.5% of the total oil. The essential oil was found to be rich in germacrene D (21.1 ± 0.4%), bicyclogermacrene (10.5 ± 0.5%), d-cadinene (5.6 ± 0.2%), a-copaene (5.1 ± 0.3%), and a-cadinol (5.0 ± 0.3%). Anticholinesterase activity was evaluated using Ellman method. The essential oil showed weak inhibitory activity against acetylcholinesterase (I%: 32.5%) and butyrylcholinesterase (I%: 35.4%) assays. Our findings demonstrate that the essential oil could be very useful for the characterization, pharmaceutical and therapeutic applications of the essent..... 718 hits |
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