Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb

Wan Mohd Nuzul Hakimi Wan Salleh

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Type :	Article
Subject :	Q Science (General)
ISBN :	1478-6419
Main Author :	Wan Mohd Nuzul Hakimi Wan Salleh
Title :	Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb
Hits :	45

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains & Matematik
Year of Publication :	2024
Notes :	Natural Product Research
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link
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Abstract : Universiti Pendidikan Sultan Idris

Phytochemical investigation of the leaves of Knema intermedia has led to the isolation of a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2, β-cubebin 3, bicubebin A 4, bicubebin B 5, and bicubebin C 6. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antifungal activity was tested using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. Compound 1 exhibited activity against C. albicans, C. lusitanae, and C. auris, (each with MIC/MFC value 250 µg/mL) and increased the biofilm of C. auris (64.07 ± 3.83%) and Candida lusitanae (62.90 ± 3.41%) when treated with 500 µg/mL. © 2024 Informa UK Limited, trading as Taylor & Francis Group.

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