Cytotoxic triterpenoids from Chisocheton pentandrus

Supratman, Unang

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Type :	article
Subject :	Q Science (General)
ISSN :	0031-9422
Main Author :	Supratman, Unang
Additional Authors :	Mohamad Azlan Nafiah
Title :	Cytotoxic triterpenoids from Chisocheton pentandrus

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2021
Notes :	Phytochemistry
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link

Abstract : Universiti Pendidikan Sultan Idris

Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 ?M comparing favourably with Cisplatin (13.2 ?M). ? 2021 The Author(s)

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