Acetylcholinesterase activity of crude extracts and flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King

Siti Awanis Abdullah

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Type :	article
Subject :	Q Science (General)
Main Author :	Siti Awanis Abdullah
Additional Authors :	Siti Mariam Abdul Lathiff Shajarahtunnur Jamil
Title :	Acetylcholinesterase activity of crude extracts and flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2022
Corporate Name :	Universiti Pendidikan Sultan Idris

Abstract : Universiti Pendidikan Sultan Idris

A flavonoids-rich extract and seven flavonoids from the leaves and heartwoods of A. anisophyllus Miq. and A. lowii King were investigated for their inhibitory effects against acetylcholinesterase enzyme. The flavonoids were fully characterized spectroscopically as artocarpin (1), isobavachalcone (2), pyranocycloartobiloxanthone A (3), 5,7-dihydroxy-4'-methoxy-6-prenylflavanone (4), 5-hydroxy-7,8-(2,2-dimethylchromano)-4'-methoxy-flavanone (5) 4',5-dihydroxy-6,7-(2,2-dimethylpyrano)-2'-methoxy-8-γ,γ-dimethylallylflavone (6) and 2',4'-dihydroxy-3,4-(2",2"-dimethylchromeno)-3'-prenyldihydrochalcone (7). Acetylcholinesterase inhibitory activity of the samples was determined using TLC plate with bioactivity staining based on the Ellman’s method. Pyranocycloartobiloxanthone A (3) exhibited an excellent inhibitory activity with detection limit at 7.81 μg/mL.

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