Chemical composition and cytotoxicity of the essential oil of rothmannia schoemannii tirveng

Wan Mohd Nuzul Hakimi W Salleh

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Type :	article
Subject :	Q Science (General)
ISSN :	0035-6808
Main Author :	Wan Mohd Nuzul Hakimi W Salleh
Title :	Chemical composition and cytotoxicity of the essential oil of rothmannia schoemannii tirveng

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2023
Notes :	Rivista Italiana delle Sostanze Grasse
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link

Abstract : Universiti Pendidikan Sultan Idris

The chemical composition of the essential oil of Rothmannia schoemannii Tirveng. (Rubiaceae) was investigated for the first time. The essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). In total, 28 components were identified in the essential oil, which made up 99.6% of the total oil. The essential oil is composed mainly of ?-eudesmol (30.8%), ?-cadinol (18.2%), caryophyllene oxide (6.5%), ?-cadinene (5.5%), and ?-eudesmol (5.4%). The essential oil exhibited cytotoxic activity against J5 (human hepatocellular carcinoma) and A549 (human lung adenocarcinoma) cells with IC50 values of 112.5 and 98.5 ug/mL, respectively. 2023, INNOVHUB - Stazioni Sperimentali per l'Industria S.r.l - Area Oli e Grassi. All rights reserved.

References

A. Mouly, K. Kainulainen, C. Persson, A. P. Davis, K. M. Wong, S. G. Razafimandimbison, B. Bremer, Phylogenetic structure, and clade circumscriptions in the Gardenieae complex (Rubiaceae). Taxon 63(4), 801-818 (2014).

S. K. Ling, T. Tanaka, I. Kouno, Iridoids from Rothmannia macrophylla. J Nat Prod. 64(6), 796-798 (2001).

A. M. Tan, L. C. Nicolo, J. D. Alejandro, T. Hiromitsu, Chemotaxonomic relevance of the constituents from the leaves of Rothmannia merrillii. J Chem Pharm Res. 6(6), 779-781 (2014).

N. Chaipukdee, K. Kanokmedhakul, S. Kanokmedhakul, R. Lekphrom, G. S. Pyne, Two new bioactive iridoids from Rothmannia wittii. Fitoterapia, 113, 97-101 (2016).

I. H. Burkill, A Dictionary of The Economic Products of The Malay. Ministry of Agriculture and Cooperative, Kuala Lumpur, 1966.

A. A. H. Yahaya, W. M. N. H. W. Salleh, Magnolia genus - A systematic review on the composition and biological properties of its essential oils. Riv. Ital. Sostanze Grasse, 99(3), 249-261 (2022).

F. L. M. Zaki, W. M. N. H. W. Salleh, Essential oils and biological activities of the genus Vitex (Lamiaceae) - A Review. Nat Vol Essent Oils 7(2), 1-9 (2020).

N. H. A. Kadir, W. M. N. H. W. Salleh, A systematic review on essential oils and biological activities of the genus Syzygium (Myrtaceae). Riv. Ital. Sostanze Grasse 99(2), 165-178 (2022).

W. M. N. H. W. Salleh, S. Khamis, Chemical composition and lipoxygenase activity of the leaves essential oil of Rothmannia macrophylla (Hook.f.) Bremek. J Essent Oil Bear Pl. 23(2), 331-336 (2020).

A. A. H. Yahaya, W. M. N. H. W. Salleh, N. A. Ghani, S. Khamis, N. S. Rezali, M. A. A. Juhari, Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil. Z Naturforsch C J Biosci. 77(11-12), 519-523 (2022).

W. M. N. H. W. Salleh, F. Ahmad, K. H. Yen, Chemical compositions and antimicrobial activity of the essential oils of Piper abbreviatum, P. erecticaule and P. lanatum (Piperaceae). Nat Prod Commun. 9(12), 1795-1798 (2014).

R. P. Adams, Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy. Allured Publishing Co. Carol Stream, Illinois, 1995.

Y. C. Su, C. L. Ho, Composition, in vitro cytotoxicity, anti-mildew and anti-wood-decay fungal activities of the fruit essential oil of Liquidambar formosana from Taiwan. Nat Prod Commun. 12(2), 287-290 (2017).

K. Marjo, P. Eija, E. S. James, Variation in volatile compounds from tansy (Tanacetum vulgare L.) related to genetic and morphological differences of genotypes. Biochem Syst Eco. 29, 267-285 (2001).

W. M. N. H. W. Salleh, S. Khamis, M. A. Nafiah, Chemical composition and anticholinesterase inhibitory activity of Dipterocarpus cornutus Dyer essential oil. Z Naturforsch C J Biosci. 75(5-6), 171-175 (2020).

Y. Li, T. Li, C. Miao, J. Li, W. Xiao, E. Ma, betaEudesmol induces JNK-dependent apoptosis through the mitochondrial pathway in HL60 cells. Phytother Res. 27, 338-343 (2013).

K. Kotawong, W. Chaijaroenkul, P. Muhamad, K. Na-Bangchang, Cytotoxic activities and effects of atractylodin and beta-eudesmol on the cell cycle arrest and apoptosis on cholangio carcinoma cell line. J Pharmacol Sci. 136, 51-56 (2018).

P. Srijiwangsa, S. Ponnikorn, K. Na-Bangchang, Effect of beta-Eudesmol on NQO1 suppressionenhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents. BMC Pharmacol Toxicol. 19, 32 (2018).

V. B. Mathema, W. Chaijaroenkul, J. Karbwang, K. Na-Bangchang, Growth inhibitory effect of beta-eudesmol on cholangiocarcinoma cells and its potential suppressive effect on heme oxygenase-1 production, STAT1/3 activation, and NF-kappaB downregulation. Clin Exp Pharmacol Physiol. 44, 1145-1154 (2017).

T. Plengsuriyakarn, J. Karbwang, K. NaBangchang, Anticancer activity using positron emission tomography- computed tomography and pharmacokinetics of beta-eudesmol in human cholangiocarcinoma xenografted nude mouse model. Clin Exp Pharmacol Physiol. 42, 293-304 (2015)

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