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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| The chemical composition, antifungal, antibiofilm, and molecular docking studies of the essential oil obtained from Lindera caesia were investigated. A total of thirty-nine components (96.7%) were identified using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The major components included terpinen-4-ol (26.3%), neo-intermedeol (23.2%), eudesma-4,11-dien-3-one (10.4%), and o-cymene (5.3%). The antifungal activity was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. The essential oil exhibited activity against C. albicans (MIC 125 g/mL) and S. mutans (MIC 250 g/mL), and increased the biofilm of C. albicans by 31.25% when treated with 500 g/mL. The molecular docking study shows neo-intermedeol, eudesma-4,11-dien-3-one, ?-selinene, and ?-selinene as the good candidate to target Erg11 with a binding energy of ?7.3 kcal/mol. These findings demonstrated that the essential oil may have potential in dental application for caries prevention. 2023 Informa UK Limited, trading as Taylor & Francis Group. |
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