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Type :article
Subject :Q Science (General)
ISSN :0972-060X
Main Author :Wan Mohd Nuzul Hakimi Wan Salleh
Title :Chemical composition, anti-tyrosinase activity and molecular docking studies of knema malayana warb. essential oil
Place of Production :Tanjung Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2023
Notes :Journal of Essential Oil-Bearing Plants
Corporate Name :Universiti Pendidikan Sultan Idris
HTTP Link :Click to view web link

Abstract : Universiti Pendidikan Sultan Idris
Essential oils produced from aromatic plants denote significant biological activities and are gaining prominence in scientific research. In this study, the chemical composition, anti-tyrosinase activity, and molecular docking studies of Knema malayana Warb. essential oil was investigated. A hydrodistillation method was used to produce the essential oil, characterised by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS). Additionally, anti-tyrosinase activity was evaluated against mushroom tyrosinase, while molecular docking studies were performed with the major components. A total of 38 components (98.9%) were successfully identified in the essential oil, which was characterised by high proportions of ?-cadinene (20.2%), ?-cadinol (13.7%), ?-amorphene (10.3%), ?-cadinene (6.3%), ?-gurjunene (5.3%), ?-gurjunene (5.3%), and ?-muurolene (5.0%). The essential oil demonstrated moderate activity towards tyrosinase activity with an IC50 value of 85.3 ?g/mL. Consequently, the best docking energy was observed with ?-amorphene (-6.9 Kcal/mol), which successfully formed interactions with His263, Phe264, and Val283. These interactions were essential amino acid residues of the tyrosinase receptor. 2023 Har Krishan Bhalla & Sons.

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