UPSI Digital Repository (UDRep)
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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| The genus Knema Lour. is distributed mainly in Southeast Asian and widely used in folk medicine for treating diseases such as jaundice, chronic fever, and inflammation. The chemical composition, acetylcholinesterase inhibition, and molecular docking studies of essential oil from Knema hookeriana Warb. were investigated in this study. The essential oil was achieved through hydrodistillation and was characterised using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The acetylcholinesterase inhibitory activity was evaluated using Ellman method while molecular docking studies were carried out using Autodock v.4.3.2. The results revealed that the essential oil examined consisted mainly of ?-caryophyllene (26.2%), germacrene D (12.5%), ?-cadinene (9.2%), germacrene B (8.8%) and bicyclogermacrene (5.5%). The essential oil showed acetylcholinesterase activity with IC50 value of 70.5 g/mL. The enzyme-ligand molecular docking study showed that ?-caryophyllene and ?-cadinene exhibited good binding affinities towards AChE with docking scores ?8.1 kcal/mol and ?8.3 kcal/mol, respectively. 2023 Informa UK Limited, trading as Taylor & Francis Group. |
| References |
Akhtar, M. N., Lam, K. W., Abas, F., Maulidiani, Ahmad, S., Shah, S. A. A., Atta-Ur-Rahman, Choudhary, M. I., & Lajis, N. Hj. (2011). New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights. Bioorganic and Medicinal Chemistry Letters, 21(13), 4097–4103. https://doi.org/10.1016/j.bmcl.2011.04.065 Alen, Y., Nakajima, S., Baba, N., Kanzaki, H., Kawazu, K., & Nitoda, T. (2000). Antinematodal Activity of Some Tropical Rainforest Plants against the Pinewood Nematode, Bursaphelenchus xylophilus. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 55(3–4), 295–299. https://doi.org/10.1515/znc-2000-3-425 Ashokkumar, K., Vellaikumar, S., Muthusamy, M., Dhanya, M. K., & Aiswarya, S. (2021). Compositional variation in the leaf, mace, kernel, and seed essential oil of nutmeg (Myristica fragrans Houtt.) from the Western Ghats, India. Natural Product Research, 36(1), 432–435. https://doi.org/10.1080/14786419.2020.1771713 Chuenban, C., Sombatsri, A., Sribuhom, T., Pornchoo, C., Prawan, A., Tontapha, S., Amornkitbamrung, V., & Yenjai, C. (2021). Knecorticosanones C-H from the fruits of: Knema globularia (Lam.) warb. RSC Advances, 11(7), 4097–4103. https://doi.org/10.1039/d0ra10498a Ellman, G. L., Courtney, K. D., Andres Jr., V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2). https://doi.org/10.1016/0006-2952(61)90145-9 Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., Torre, C. L., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., & Sinicropi, M. S. (2019). β-caryophyllene: A sesquiterpene with countless biological properties. Applied Sciences (Switzerland), 9(24). https://doi.org/10.3390/app9245420 Gény, C., Rivière, G., Bignon, J., Birlirakis, N., Guittet, E., Awang, K., Litaudon, M., Roussi, F., & Dumontet, V. (2016). Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions. Journal of Natural Products, 79(4), 838–844. https://doi.org/10.1021/acs.jnatprod.5b00915 Giap, T. H., Duc, P. M., van The, N., Popova, M., Bankova, V., Hue, C. T., Kim Oanh, V. T., Minh Hang, N. T., Van, H. N., & Le, T. N. (2021). Chemical constituents and biological activities of the fruits of Knema pachycarpa de Wilde. Natural Product Research, 35(3), 455–464. https://doi.org/10.1080/14786419.2019.1637868 Gonzalez, M. J. T. G., DeOliveira, C. J. C., Fernandes, J. O., Kijjoa, A., & Herz, W. (1996). Further alkyl and alkenylphenols of Knema laurina and Knema austrosiamensis: Location of the double bond in the alkenyl side chains. Phytochemistry, 43(6), 1333–1337. https://doi.org/10.1016/S0031-9422(96)00413-X Hiruma-Lima, C. A., Batista, L. M., de Almeida, A. B. A., de Pietro Magri, L., dos Santos, L. C., Vilegas, W., & Brito, A. R. M. S. (2009). Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae). Journal of Ethnopharmacology, 122(2), 406–409. https://doi.org/10.1016/j.jep.2008.12.023 Ismail, N., Akhtar, M. N., Ismail, M., Zareen, S., Shah, S. A. A., Lajis, N. H., & Tajuddin, S. N. (2015). Neuroprotective effect from stem bark extracts of Knema laurina against H Kijjoa, A., Gonzalez, M. J. T. G., Pinto, M. M. M., Monanondra, I.-O., & Herz, W. (1991). Constituents of Knema laurina and Knema tenuinervia ssp. setosa. Planta Medica, 57(6), 575–577. https://doi.org/10.1055/s-2006-960210 Mohammadhosseini, M., Venditti, A., Frezza, C., Serafini, M., Bianco, A., & Mahdavi, B. (2021). The genus haplophyllum juss.: Phytochemistry and bioactivities—A review. Molecules, 26(15). https://doi.org/10.3390/molecules26154664 Olaoluwa, O., Taiwo, O., Nahar, L., & Sarker, S. D. (2022). Ethnopharmacology, phytochemistry and biological activities of selected African species of the genus Ficus. Trends in Phytochemical Research, 6(1), 46–69. https://doi.org/10.30495/tpr.2022.1939285.1219 Pham, T. V., Bach, H. K. T., Ho, D. V., & Nguyen, B. C. (2021). Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity. Natural Product Research, 36(1), 256–262. https://doi.org/10.1080/14786419.2020.1777416 Sabulal, B., Kurup, R., Sumitha, B., & George, V. (2007). Chemical composition of the leaf oils of myristica malabarica lam. and gymnacranthera canarica (king) warb. Journal of Essential Oil Research, 19(4), 323–325. https://doi.org/10.1080/10412905.2007.9699293 Salleh, W. M. N. H. W., & Ahmad, F. (2017). Phytochemistry and biological activities of the genus Knema (Myristicaceae). Pharmaceutical Sciences, 24(4), 249–255. https://doi.org/10.15171/ps.2017.37 Salleh, W. M. N. H. W., Anuar, M. Z. A., Khamis, S., Nafiah, M. A., & Sul’ain, M. D. (2021). Chemical investigation and biological activities of the essential oil of Knema kunstleri Warb. from Malaysia. Natural Product Research, 35(13), 2279–2284. https://doi.org/10.1080/14786419.2019.1669027 Salleh, W. M. N. H. W., Khamis, S., Nafiah, M. A., & Abed, S. A. (2021). Chemical composition and anticholinesterase inhibitory activity of the essential oil of Pseuduvaria macrophylla (Oliv.) Merr. from Malaysia. Natural Product Research, 35(11), 1887–1892. https://doi.org/10.1080/14786419.2019.1639183 Sriphana, U., Yenjai, C., & Koatthada, M. (2016). Cytotoxicity of chemical constituents from the roots of Knema globularia. Phytochemistry Letters, 16, 129–133. https://doi.org/10.1016/j.phytol.2016.03.010 Sriphana, U., Yenjai, C., Suthiwong, J., & Poopasit, K. (2022). A new diarylhexane and two new diarylpropanols from the roots of Knema globularia. Natural Product Research, 36(7), 1741–1748. https://doi.org/10.1080/14786419.2020.1815736 Wiart, C. (2006). Medicinal plants of Asia and the Pacific. In Medicinal Plants of Asia and the Pacific. Ziyatdinova, G., Ziganshina, E., Cong, P. N., & Budnikov, H. (2016). Ultrasound-assisted micellar extraction of phenolic antioxidants from spices and antioxidant properties of the extracts based on coulometric titration data. Analytical Methods, 8(39), 7150–7157. https://doi.org/10.1039/c6ay02112c |
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