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Chemical composition, acetylcholinesterase inhibition and molecular docking studies of essential oil from Knema hookeriana Warb. (Myristicaceae)

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General Information
Title
Chemical composition, acetylcholinesterase inhibition and molecular docking studies of essential oil from Knema hookeriana Warb. (Myristicaceae)
Type
Article
Main Author
Wan Mohd Nuzul Hakimi Wan Salleh
Subject
Q Science (General)
ISSN
1478-6419
Language Code
eng
Bibliographic Details
Place of Production
Tanjung Malim
Publisher
Fakulti Sains dan Matematik
Year of publication
2024
Notes
Natural Product Research
Degree Type
Others
Corporate Name
Universiti Pendidikan Sultan Idris

Abstract

The genus Knema Lour. is distributed mainly in Southeast Asian and widely used in folk medicine for treating diseases such as jaundice, chronic fever, and inflammation. The chemical composition, acetylcholinesterase inhibition, and molecular docking studies of essential oil from Knema hookeriana Warb. were investigated in this study. The essential oil was achieved through hydrodistillation and was characterised using gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The acetylcholinesterase inhibitory activity was evaluated using Ellman method while molecular docking studies were carried out using Autodock v.4.3.2. The results revealed that the essential oil examined consisted mainly of ?-caryophyllene (26.2%), germacrene D (12.5%), ?-cadinene (9.2%), germacrene B (8.8%) and bicyclogermacrene (5.5%). The essential oil showed acetylcholinesterase activity with IC50 value of 70.5 g/mL. The enzyme-ligand molecular docking study showed that ?-caryophyllene and ?-cadinene exhibited good binding affinities towards AChE with docking scores ?8.1 kcal/mol and ?8.3 kcal/mol, respectively. 2023 Informa UK Limited, trading as Taylor & Francis Group.

References

Akhtar, M. N., Lam, K. W., Abas, F., Maulidiani, Ahmad, S., Shah, S. A. A., Atta-Ur-Rahman, Choudhary, M. I., & Lajis, N. Hj. (2011). New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights. Bioorganic and Medicinal Chemistry Letters, 21(13), 4097–4103. https://doi.org/10.1016/j.bmcl.2011.04.065.

Alen, Y., Nakajima, S., Baba, N., Kanzaki, H., Kawazu, K., & Nitoda, T. (2000). Antinematodal Activity of Some Tropical Rainforest Plants against the Pinewood Nematode, Bursaphelenchus xylophilus. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 55(3–4), 295–299. https://doi.org/10.1515/znc-2000-3-425.

Ashokkumar, K., Vellaikumar, S., Muthusamy, M., Dhanya, M. K., & Aiswarya, S. (2021). Compositional variation in the leaf, mace, kernel, and seed essential oil of nutmeg (Myristica fragrans Houtt.) from the Western Ghats, India. Natural Product Research, 36(1), 432–435. https://doi.org/10.1080/14786419.2020.1771713.

Chuenban, C., Sombatsri, A., Sribuhom, T., Pornchoo, C., Prawan, A., Tontapha, S., Amornkitbamrung, V., & Yenjai, C. (2021). Knecorticosanones C-H from the fruits of: Knema globularia (Lam.) warb. RSC Advances, 11(7), 4097–4103. https://doi.org/10.1039/d0ra10498a.

Ellman, G. L., Courtney, K. D., Andres Jr., V., & Featherstone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2). https://doi.org/10.1016/0006-2952(61)90145-9.

Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., Torre, C. L., Ceramella, J., Mallamaci, R., Saturnino, C., Iacopetta, D., & Sinicropi, M. S. (2019). β-caryophyllene: A sesquiterpene with countless biological properties. Applied Sciences (Switzerland), 9(24). https://doi.org/10.3390/app9245420.

Gény, C., Rivière, G., Bignon, J., Birlirakis, N., Guittet, E., Awang, K., Litaudon, M., Roussi, F., & Dumontet, V. (2016). Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions. Journal of Natural Products, 79(4), 838–844. https://doi.org/10.1021/acs.jnatprod.5b00915.

Giap, T. H., Duc, P. M., van The, N., Popova, M., Bankova, V., Hue, C. T., Kim Oanh, V. T., Minh Hang, N. T., Van, H. N., & Le, T. N. (2021). Chemical constituents and biological activities of the fruits of Knema pachycarpa de Wilde. Natural Product Research, 35(3), 455–464. https://doi.org/10.1080/14786419.2019.1637868.

Gonzalez, M. J. T. G., DeOliveira, C. J. C., Fernandes, J. O., Kijjoa, A., & Herz, W. (1996). Further alkyl and alkenylphenols of Knema laurina and Knema austrosiamensis: Location of the double bond in the alkenyl side chains. Phytochemistry, 43(6), 1333–1337. https://doi.org/10.1016/S0031-9422(96)00413-X.

Hiruma-Lima, C. A., Batista, L. M., de Almeida, A. B. A., de Pietro Magri, L., dos Santos, L. C., Vilegas, W., & Brito, A. R. M. S. (2009). Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae). Journal of Ethnopharmacology, 122(2), 406–409. https://doi.org/10.1016/j.jep.2008.12.023.

Ismail, N., Akhtar, M. N., Ismail, M., Zareen, S., Shah, S. A. A., Lajis, N. H., & Tajuddin, S. N. (2015). Neuroprotective effect from stem bark extracts of Knema laurina against H2O2-and Aβ1-42-induced cell death in human SH-SY5Y cells. Natural Product Research, 29(16), 1571–1574. https://doi.org/10.1080/14786419.2014.985676.

Kijjoa, A., Gonzalez, M. J. T. G., Pinto, M. M. M., Monanondra, I.-O., & Herz, W. (1991). Constituents of Knema laurina and Knema tenuinervia ssp. setosa. Planta Medica, 57(6), 575–577. https://doi.org/10.1055/s-2006-960210.

Mohammadhosseini, M., Venditti, A., Frezza, C., Serafini, M., Bianco, A., & Mahdavi, B. (2021). The genus haplophyllum juss.: Phytochemistry and bioactivities—A review. Molecules, 26(15). https://doi.org/10.3390/molecules26154664.

Olaoluwa, O., Taiwo, O., Nahar, L., & Sarker, S. D. (2022). Ethnopharmacology, phytochemistry and biological activities of selected African species of the genus Ficus. Trends in Phytochemical Research, 6(1), 46–69. https://doi.org/10.30495/tpr.2022.1939285.1219.

Pham, T. V., Bach, H. K. T., Ho, D. V., & Nguyen, B. C. (2021). Chemical constituents from the Knema globularia fruits and their in vitro cytotoxicity. Natural Product Research, 36(1), 256–262. https://doi.org/10.1080/14786419.2020.1777416.

Sabulal, B., Kurup, R., Sumitha, B., & George, V. (2007). Chemical composition of the leaf oils of myristica malabarica lam. and gymnacranthera canarica (king) warb. Journal of Essential Oil Research, 19(4), 323–325. https://doi.org/10.1080/10412905.2007.9699293.

Salleh, W. M. N. H. W., & Ahmad, F. (2017). Phytochemistry and biological activities of the genus Knema (Myristicaceae). Pharmaceutical Sciences, 24(4), 249–255. https://doi.org/10.15171/ps.2017.37.

Salleh, W. M. N. H. W., Anuar, M. Z. A., Khamis, S., Nafiah, M. A., & Sul’ain, M. D. (2021). Chemical investigation and biological activities of the essential oil of Knema kunstleri Warb. from Malaysia. Natural Product Research, 35(13), 2279–2284. https://doi.org/10.1080/14786419.2019.1669027.

Salleh, W. M. N. H. W., Khamis, S., Nafiah, M. A., & Abed, S. A. (2021). Chemical composition and anticholinesterase inhibitory activity of the essential oil of Pseuduvaria macrophylla (Oliv.) Merr. from Malaysia. Natural Product Research, 35(11), 1887–1892. https://doi.org/10.1080/14786419.2019.1639183.

Sriphana, U., Yenjai, C., & Koatthada, M. (2016). Cytotoxicity of chemical constituents from the roots of Knema globularia. Phytochemistry Letters, 16, 129–133. https://doi.org/10.1016/j.phytol.2016.03.010.

Sriphana, U., Yenjai, C., Suthiwong, J., & Poopasit, K. (2022). A new diarylhexane and two new diarylpropanols from the roots of Knema globularia. Natural Product Research, 36(7), 1741–1748. https://doi.org/10.1080/14786419.2020.1815736.

Wiart, C. (2006). Medicinal plants of Asia and the Pacific. In Medicinal Plants of Asia and the Pacific.

Ziyatdinova, G., Ziganshina, E., Cong, P. N., & Budnikov, H. (2016). Ultrasound-assisted micellar extraction of phenolic antioxidants from spices and antioxidant properties of the extracts based on coulometric titration data. Analytical Methods, 8(39), 7150–7157. https://doi.org/10.1039/c6ay02112c.


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