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Type :article
Subject :GV Recreation Leisure
ISSN :1517-8692
Main Author :Elumalai, Gunathevan
Additional Authors :Siti Hartini Azmi
Title :Biosensor development in sports doping with dexamethasone
Place of Production :Tanjung Malim
Publisher :Fakulti Sains Sukan Dan Kejurulatihan
Year of Publication :2023
Notes :Revista Brasileira de Medicina do Esporte
Corporate Name :Universiti Pendidikan Sultan Idris
HTTP Link :Click to view web link

Abstract : Universiti Pendidikan Sultan Idris
Introduction: Dexamethasone is a type of drug that is considered a steroid. It belongs to a class of drugs known as corticosteroids. Objective: Develop an electrochemical sensor of dexamethasone in a pharmaceutical sample using electrodes modified with nanostructures of MnO2 and reduced graphene oxide (MnO2/rGO). The glassy carbon electrodes (GCE) used to make the GO nanostructures were first modified using a modified Hummers technique before electrochemically reduced. Methods: MnO2 nanomaterials were electrochemi-cally deposited on rGO/GCE. SEM structural investigation indicated vertical tetragonal crystal development of-MnO2 nanostructures in sprayed rGO nanostructures. Results: Because of the high composite surface area, multiple exposed active sites, and the synergistic effect of MnO2 and rGO, the electrocatalytic reaction to dexamethasone of MnO2/rGO/CPE was shown to be broad, selective, stable, and sensitive in electrochemical tests using amperometry. It was established that the linear range, sensitivities, and detection limit of the sensor are 0 to 260 M, 4.6153A/M and 0.005 M, respectively. The MnO2/rGO/CPE was tested for accuracy and applicability in determining dexamethasone in pharmacological and human urine samples. Conclusion: The results revealed that the sensor could prepare acceptable recovery (96.34%) and RSD (3.58%), suggesting that it could be used as a reliable dexamethasone sensor in clinical samples. Level of evidence II; Therapeutic studies-Investigation of treatment outcomes. 2023, Redprint Editora Ltda. All rights reserved.

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