VOLATILE COMPONENTS OF Dillenia reticulata King (DILLENIACEAE) ESSENTIAL OIL AND THEIR CYTOTOXICITY

Wan Mohd Nuzul Hakimi Wan Salleh

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Type :	article
ISSN :	1011-3924
Main Author :	Wan Mohd Nuzul Hakimi Wan Salleh
Title :	VOLATILE COMPONENTS OF Dillenia reticulata King (DILLENIACEAE) ESSENTIAL OIL AND THEIR CYTOTOXICITY

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2023
Notes :	Bulletin of the Chemical Society of Ethiopia
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link

Abstract : Universiti Pendidikan Sultan Idris

This work aimed to investigate, for the first time, the chemical composition and cytotoxicity of Dillenia reticulata King's essential oil. The essential oil was obtained through hydrodistillation, and its volatile components were analyzed through gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS) techniques. Twelve components, which constitutes more than 99.49% of oil content, were successfully identified. The most prominent components were bicyclogermacrene (44.18%), germacrene D (14.49%), ?-gurjunene (12.59%), and elemol (12.25%). The cytotoxicity of essential oil was evaluated using an MTT assay. The essential oil exhibited cytotoxicity against three cancer cell lines which are HepG2, MCF7 and A549 with the IC50 values ranging from 61.5-68.5 ?g/mL. The present study highlights the potential of using essential oil as an alternative for the development of chemopreventive or cosmetic agents for the pharmaceutical industry. 2023 Chemical Society of Ethiopia and The Authors.

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