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Morphinan alkaloids from the leaves of alphonsea cylindrica and their antibacterial properties

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General Information Cached
Title
Morphinan alkaloids from the leaves of alphonsea cylindrica and their antibacterial properties
Type
Article
Main Author
Mohd Azlan Nafiah
Subject
Q Science (General)
ISSN
0032-0943
Language Code
eng
Bibliographic Details
Place of Production
Tanjung Malim
Publisher
Fakulti Sains dan Matematik
Year of publication
2023
Notes
Planta Medica
Degree Type
Not related
Corporate Name
Universiti Pendidikan Sultan Idris

Abstract

A phytochemical study has been carried out on CH 2Cl 2extract of Alphonsea cylindrica leaves, resulting in the isolation of three new morphinan alkaloids. They are kinomenine (1), N -methylkinomenine (2), and hydroxymethylkinomenine (3). The structures of these compounds were elucidated by extensive spectroscopic analysis (1D and 2D NMR, IR, UV, HRESIMS) and comparison with the data reported in literature for similar alkaloids. Kinomenine (1) and N -methylkinomenine (2) showed weak inhibition against S. aureus (MIC values of 1 and 2 = 500 ?g/mL; pIC 50values in 95% C.?I. of: 1 = 2.9 to 3.0; 2 = 2.9 to 3.1), while kinomenine (1) also showed weak inhibition against E. coli (MIC values of 1 = 500 ?g/mL; pIC 50value in 95% C.?I. of: 1 = 2.9) by broth microdilution method. The results obtained can be used as future referencefor the discovery of morphinans and the potential of A. cylindrica as an antibacterial source. 2023 Georg Thieme Verlag. All rights reserved.

References

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