Morphinan Alkaloids from the Leaves of Alphonsea cylindrica and Their Antibacterial Properties

Mohd Azlan Nafiah

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Type :	article
ISSN :	0032-0943
Main Author :	Mohd Azlan Nafiah
Title :	Morphinan Alkaloids from the Leaves of Alphonsea cylindrica and Their Antibacterial Properties

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2023
Notes :	Planta Medica
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link

Abstract : Universiti Pendidikan Sultan Idris

A phytochemical study has been carried out on CH 2Cl 2extract of Alphonsea cylindrica leaves, resulting in the isolation of three new morphinan alkaloids. They are kinomenine (1), N -methylkinomenine (2), and hydroxymethylkinomenine (3). The structures of these compounds were elucidated by extensive spectroscopic analysis (1D and 2D NMR, IR, UV, HRESIMS) and comparison with the data reported in literature for similar alkaloids. Kinomenine (1) and N -methylkinomenine (2) showed weak inhibition against S. aureus (MIC values of 1 and 2 = 500 ?g/mL; pIC 50values in 95% C.?I. of: 1 = 2.9 to 3.0; 2 = 2.9 to 3.1), while kinomenine (1) also showed weak inhibition against E. coli (MIC values of 1 = 500 ?g/mL; pIC 50value in 95% C.?I. of: 1 = 2.9) by broth microdilution method. The results obtained can be used as future referencefor the discovery of morphinans and the potential of A. cylindrica as an antibacterial source. 2023 Georg Thieme Verlag. All rights reserved.

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