Chemical composition of the Essential oil of Litsea resinosa blume and acetylcholinesterase activity

Abubakar Siddiq Salihu

Abstract

The essential oil of Litsea resinosa Blume (Lauraceae) was obtained by hydrodistillation and was fully characterized by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of twenty-eight components were identified in the essential oil, which made up 90.8% of the total oil. The essential oil consists mainly of β-caryophyllene (22.5%), α-humulene (15.4%), caryophyllene oxide (9.2%), germacrene D (5.6%), and β-selinene (5.0%). The essential oil showed significant activity against acetylcholinesterase with a percentage inhibition of 72.4%. Keywords: Litsea resinosa, Lauraceae, essential oil, caryophyllene, acetylcholinesterase

References

Abdullah SA, Lathiff SMA, Jamil S. (2022). Acetylcholinesterase activity of crude extracts and flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King. Journal of Science and Mathematics Letters, 10(2), 62-66.

Adams RP. (2007). Identification of essential oil components by gas chromatography-mass spectrometry. 4th Ed. Carol Stream (IL): Allured Publishing Corporation.

Ahmad FB, Jantan IB, Bakar BA, Ahmad AS. (2005). A comparative study of the composition of the leaf oils of three Litsea species from Borneo. Journal of Essential Oil Research, 17(3), 323-326.

Azhar MAM, Salleh WMNHW, Khamis S, Ghani NA. (2022). Variation in essential oil composition of three Litsea species from Malaysia. Rivista Italiana Delle Sostanze Grasse, 99(1), 57-61.

Kong DG, Zhao Y, Li GH, Chen BJ, Wang XN, Zhou HL, Lou HX, Ren DM, Shen T. (2015). The genus Litsea in traditional Chinese medicine: an ethnomedical, phytochemical and pharmacological review. Journal of Ethnopharmacology, 164, 256-264.

Salleh WMNHW, Ahmad F, Khong HY, Zulkifli RM. (2016). Chemical composition and biological activities of essential oil of Beilschmiedia pulverulenta. Pharmaceutical Biology, 54(2), 322-330.

Salleh WMNHW, Khamis S, Abed SA. (2021). Characterization of volatile components of Chassalia chartacea and its acetylcholinesterase inhibitory activity. Chemistry of Natural Compounds, 57(2), 376-377.

Salleh WMNHW, Khamis S. (2021). Essential oil of Thottea grandiflora and its lipoxygenase inhibitory activity. Chemistry of Natural Compounds, 57(5), 959-960.

Wong MH, Lim LF, Ahmad FB, Assim ZB. (2014). Antioxidant and antimicrobial properties of Litsea elliptica Blume and Litsea resinosa Blume (Lauraceae). Asian Pacific Journal of Tropical Biomedicine, 4(5), 386-392.