UPSI Digital Repository (UDRep)
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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Essential oils, a volatile mixture derived from plants, have shown a wide biological activity, and have been used as ancient remedies for the treatment of various diseases. The objective of this study was to investigate the chemical composition and cytotoxicity of the essential oil obtained from Garcinia urophylla leaves collected from Malaysia. Eighteen components were identified using gas chromatography-flame ionisation detection (GC-FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.9% of the essential oil. The major components were β-caryophyllene (56.2%), α-humulene (26.3%), and α-gurjunene (6.3%). The cytotoxicity of essential oil was evaluated using an MTT assay. The essential oil exhibited cytotoxicity against three cancer cell lines which are HepG2, MCF7, and A549 with the IC50 values of 71.5, 56.2, and 68.5 μg/ mL, respectively. To the best of our knowledge, this is the first report on the essential oil composition obtained from Garcinia urophylla, which may have implications on the pharmaceutical and therapeutic applications of Garcinia genus essential oils. © 2024, INNOVHUB - Stazioni Sperimentali per l'Industria S.r.l - Area Oli e Grassi. All rights reserved. |
| References |
W.M.N.H.W. Salleh, N.A. Ghani, A.B.M. Abdel- Aal. Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil. Z. Naturforsch. C J. Biosci. 77(11-12), 525-529 (2022). A.A.H. Yahaya, W.M.N.H.W. Salleh, N.A. Ghani, S. Khamis, N.S. Rezali, M.A.A. Juhari. Chemical composition and bioactivities of Magnolia candollii H.Keng essential oil. Z. Naturforsch. C J. Biosci. 77(11-12), 519-523 (2022). W.M.N.H.W. Salleh, S. Khamis. Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil. Z. Naturforsch. C J. Biosci. 75, 467-71 (2020). W.M.N.H.W. Salleh, F. Ahmad, K.H. Yen, R.M. Zulkifli. Chemical composition and biological activities of essential oil of Beilschmiedia pulverulenta. Pharm. Biol. 54(2), 322-330 (2016). W.M.N.H.W. Salleh, M.F. Kammil, F. Ahmad, H.M. Sirat. Antioxidant and anti-inflammatory activities of essential oil and extracts of Piper miniatum. Nat. Prod. Commun. 10(11), 2005-2008 (2015). K. Blowman, M. Magalhaes, M.F.L. Lemos, C. Cabral, I.M. Pires. Anticancer properties of essential oils and other natural products. Evid. Based Complement. Altern. Med. 3149362 (2018). E.J.H. Corner. Wayside trees of Malaya. Vol. 1. Singapore: Government Printing Office, 1952. B. Liu, X. Zhang, R.W. Bussmann, R.H. Hart, P. Li, Y. Bai, C. Long. Garcinia in Southern China:Ethnobotany, Management and Niche Modeling. Econ. Bot. 70(4), 416-430 (2016). O. Chantarasriwong, A. Batova, W. Chavasiri, E.A. Theodorakis. Chemistry and biology of the caged Garcinia xanthones. Chem. Eur. J. 16, 9944-9962 (2010). D. Obolskiy, I. Pischel, N. Siriwatanametanon, M. Heinrich. Garcinia mangostana L.: A phytochemical and pharmacological review. Phytother. Res. 23, 1047-1065 (2009). I.H. Burkill. A dictionary of the economic product of Malay Peninsula. Kuala Lumpur: Ministry of Agriculture and Co-operatives, 1966. M.L. Jabit, F.S. Wahyuni, R. Khalid, D.A. Israf, K. Shaari, N.H. Lajis, J. Stanslas. Cytotoxic and nitric oxide inhibitory activities of methanol extracts of Garcinia species. Pharm. Biol. 47(11), 1019-1026 (2009). R.M. Khalid, Md.L. Jabit, F. Abas, J. Stanslas, K. Shaari, N.H. Lajis. Cytotoxic xanthones from the leaves of Garcinia urophylla. Nat. Prod. Commun. 2(3), 271-276 (2007). W.M.N.H.W. Salleh, S. Khamis. Essential oil composition of Garcinia nigrolineata Planch. ex T.Anderson (Clusiaceae). Agric. Conspec. Sci. 86(4), 375-378 (2022). W.M.N.H.W. Salleh, S. On, F. Ahmad, H.M. Sirat, M. Taher, S.D. Sarker, L. Nahar. A new xanthone and a new benzophenone from the roots of Garcinia hombroniana. Phytochem. Lett. 35, 216-219 (2020). W.M.N.H.W. Salleh, N.S.A.N. Sazali, F. Ahmad. Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities. Marmara Pharm. J. 21(4), 889-897 (2017). S. On, W.M.N.H.W. Salleh, F. Ahmad, H.M. Sirat, M. Taher. Cytotoxicity of triterpenes from the leaves of Garcinia prainiana King (Guttiferae). Marmara Pharm. J. 21(1), 127-131 (2017). R.P. Adams. Identification of essential oil components by gas chromatography-mass spectrometry. 4th ed. Carol Stream (IL): Allured Publishing Corporation, 2007. W.M.N.H.W. Salleh, N.A. Muhammad, N.A. Ghani, M.H. Jauri. Volatile components of Dillenia reticulata King (Dilleniaceae) essential oil and their cytotoxicity. Bull. Chem. Soc. Ethiop. 37(1), 245-249 (2023). W.M.N.H.W. Salleh, S. Khamis. Essential oil composition of Garcinia nigrolineata Planch. ex T. Anderson (Clusiaceae). Agric. Conspec. Sci. 86(4), 375-378 (2021). W.N. Tan, W.Y. Tong, C.R. Leong, N.N.S. Nik Mohamed Kamal, M. Muhamad, J.W. Lim, M. Khairuddean, M.B. Her Man. Chemical composition of essential oil of Garcinia gummi-gutta and its antimicrobial and cytotoxic activities. J. Essent. Oil Bear. Pl. 23(4), 832-842 (2020). W.N. Tan, Z.H. Tan, N.I. Zulkifli, N.N.S. Nik Mohamed Kamal, N.A.S. Rozman, W.Y. Tong, C.R. Leong, J.W. Lim. Sesquiterpenes rich essential oil from Garcinia celebica L. and its cytotoxic and antimicrobial activities. Nat. Prod. Res. 34(23), 3404-3408 (2020). |
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