UPSI Digital Repository (UDRep)
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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Knema furfuracea Warb., a tree species belonging to the family Myristicaceae and indigenous to Southeast Asia, has been traditionally used by the Dai people for the treatment of inflammation and other illnesses. This work investigates the chemical composition of the essential oil of K. furfuracea, antityrosinase activity, and molecular docking studies. The essential oil was obtained through hydrodistillation and characterised through gas chromatography (GC/FID) and gas chromatography mass spectrometry (GC/ MS). The anti-tyrosinase activity was determined using mushroom tyrosinase enzyme. The major components of the essential oil were studied for their potential interactions with tyrosinase using Autodock vina. A total of thirty-one components (96.0%) were identified from the leaf oil and composed mainly of bicyclogermacrene (23.1%), δ-cadinene (17.2%), (E,E)-α-farnesene (9.1%), and β-caryophyllene (7.7%). The essential oil demonstrated moderate activity towards tyrosinase with an IC50 value of 80.3 µg/mL. Regarding the molecular docking study, β-caryophyllene indicated a strong inhibitory activity (–6.7 Kcal/mol). These findings suggest that K. furfuracea essential oil has the potential as a natural source of tyrosinase inhibitors. © 2024, INNOVHUB - Stazioni Sperimentali per l'Industria S.r.l - Area Oli e Grassi. All rights reserved. |
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