Tween–80 coating in enhancing physicochemical stability, kinetics and release mechanism of layered double hydroxide-ferulate

Sharifah Norain Mohd Sharif

Abstract

This study aims to enhance the targeted delivery of a powerful antioxidant, ferulate (FA), by developing a controlled release formulation (CRF) based on the incorporation of layered double hydroxide and Tween-80 polymeric surfactant. The layered double hydroxide-ferulate (LDH-FA) synthesized by co-precipitation method was homogenously mixed with the Tween-80 coater under continuous stirring. The successful Tween-80 coating was verified with PXRD analysis and supported by FTIR. No changes in interlayer distance between LDH-FA (at 17.4 and 8.7 A) and LDH-FA-T80 (at 17.6 and 8.6 A) were observed in the PXRD pattern. TGA/DTG analysis demonstrated good thermal stability of LDH-FA-T80, with the ability to withstand extreme temperatures up to 460 _C. The association of Tween-80 with LDH-FA progressively sustained the release time of FA in each aqueous solution, with a release time of up to 440 min. For both LDH-FA and LDH-FA-T80, the release of FA is through dissolution and anion exchange release mechanism (regulated by pseudo-second-order kinetic model). The study's findings suggest practical applications of FA in the pharmaceutical industry by implying the retarding effect triggered by Tween-80, offering new insights for the application of CRF to enhance the therapeutic effect of FA. _ 2024, Gadjah Mada University. All rights reserved.

References

Sheikh Mohd Ghazali, S.A.I., Sarijo, S.H., and Hussein, M.Z., 2021, New synthesis of binate herbicide-interleaved anionic clay material: Synthesis, characterization and simultaneous controlled-release properties, J. Porous Mater., 28 (2), 495–505.

Peralta, M.F., Mendieta, S.N., Scolari, I.R., Granero, G. E., and Crivello, M. E., 2021, Synthesis and release behavior of layered double hydroxides–carbamazepine composites, Sci. Rep., 11 (1), 20585.

Rad, S., and Yazdi, E., 2021, Study of nano-dual organic-hydroxide drug delivery system for anticancer drugs, Medbiotech J., 5 (1), 22–27.

Mohiuddin, I., Grover, A., Aulakh, J.S., Malik, A.K., Lee, S.S., Brown, R.J.C., and Kim, K.H., 2021, Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants, J. Hazard. Mater., 401, 123782.

Kura, A.U., Hussein-Al-Ali, S.H., Hussein, M.Z., and Fakurazi, S., 2014, Preparation of Tween 80-Zn/Al-levodopa-layered double hydroxides nanocomposite for drug delivery system, Sci. World J., 2014, 104246.

Barkhordari, S., and Alizadeh, A., 2022, Fabrication of pH-sensitive chitosan/layered double hydroxide (LDH)/Fe3O4 nanocomposite hydrogel beads for controlled release of diclofenac, Polym. Bull., 79 (7), 5533–5548.

Liu, Z., Lansley, A.B., Duong, T.N., Smart, J.D., and Pannala, A.S., 2022, Increasing cellular uptake and permeation of curcumin using a novel polymersurfactant formulation, Biomolecules, 12 (12), 1739.

Constantino, V.R.L., Figueiredo, M.P., Magri, V.R., Eulálio, D., Cunha, V.R.R., Alcântara, A.C.S., and Perotti, G.F., 2023, Biomaterials based on organic polymers and layered double hydroxides nanocomposites: Drug delivery and tissue engineering, Pharmaceutics, 15 (2), 413.

Bozorgian, A., Aboosadi, Z.A., Mohammadi, A., Honarvar, B., and Azimi, A., 2020, Determination of CO2 gas hydrates surface tension in the presence of non-ionic surfactants and TBAC, Rev. Roum. Chim., 65 (12), 1061–1065.

Baek, S., Shin, D., Kim, G., Lee, A., Noh, J., Choi, B., Huh, S., Jeong, H., and Sung, Y., 2021, Influence of amphoteric and anionic surfactants on stability, surface tension, and thermal conductivity of Al2O3/water nanofluids, Case Stud. Therm. Eng., 25, 100995.

Mandal, S., Banerjee, C., Ghosh, S., Kuchlyan, J., and Sarkar, N., 2013, Modulation of the photophysical properties of curcumin in non-ionic surfactant (Tween-20) forming micelles and niosomes: A comparative study of different microenvironments, J. Phys. Chem. B, 117 (23), 6957–6968.

Ravichandran, V., Lee, M., Nguyen Cao, T.G., and Shim, M.S., 2021, Polysorbate-based drug formulations for brain-targeted drug delivery and anticancer therapy, Appl. Sci., 11 (19), 9336.

Nilsson, E.J., Lind, T.K., Scherer, D., Skansberger, T., Mortensen, K., Engblom, J., and Kocherbitov, V., 2020, Mechanisms of crystallisation in polysorbates and sorbitan esters, CrystEngComm, 22 (22), 3840–3853.

Lima, E., Flores, J., Cruz, A.S., Leyva-Gómez, G., and Krötzsch, E., 2013, Controlled release of ferulic acid from a hybrid hydrotalcite and its application as an antioxidant for human fibroblasts, Microporous Mesoporous Mater., 181, 1–7.

Sousa, R., da Silva, B.J.M., Dias, A.A., Meneses, C.C.F., Bentes, B.A., Silva, E.O., Remédios, C.M.R., Feio, W.P., Masson, O., Alves, C.N., Arruda, M.M.S.P., and Lameira, J., 2019, Ferulate anion intercalated into Zn/Al layered double hydroxide: A promising intercalation compound for inhibition of Leishmania (L.) amazonensis, J. Braz. Chem. Soc., 30 (6), 1178–1188.

Long, T., Wu, Q., Wei, J., Tang, Y., He, Y.N., He, C.L., Chen, X., Yu, L., Yu, C.L., Law, B.Y.K., Wu, J.M., Qin, D.L., Wu, A.G., and Zhou, X.G., 2022, Ferulic acid exerts neuroprotective effects via autophagy induction in C. elegans and cellular models of Parkinson’s disease, Oxid. Med. Cell. Longevity, 2022, 372567.

Sivakumar, S., Murali, R., Arathanaikotti, D., Gopinath, A., Senthilkumar, C., Kesavan, S., and Madhan, B., 2021, Ferulic acid loaded microspheres reinforced in 3D hybrid scaffold for antimicrobial wound dressing, Int. J. Biol. Macromol., 177, 463–473.

Mancuso, A., Cristiano, M.C., Pandolfo, R., Greco, M., Fresta, M., and Paolino, D., 2021, Improvement of ferulic acid antioxidant activity by multiple emulsions: In vitro and in vivo evaluation, Nanomaterials, 11 (2), 425.

Hwang, H.J., Lee, S.R., Yoon, J.G., Moon, H.R., Zhang, J., Park, E., Yoon, S.I., and Cho, J.A., 2022, Ferulic acid as a protective antioxidant of human intestinal epithelial cells, Antioxidants, 11 (8), 1448.

Muda, Z., Hashim, N., Isa, I., and Ali, N.M., 2016, Preparation of layered material Zn/Al-layered double hydroxide-ferulate nanocomposites, Sainmatika, 13 (2), 35–47.