Chemical composition and biological activities of essential oil of the Malaysian endemic Syzygium variolosum (King) Chantar. & J.Parn

Wan Mohd Nuzul Hakimi W SalleH

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Type :	Article
Subject :	Q Science (General)
ISBN :	1478-6419
Main Author :	Wan Mohd Nuzul Hakimi W SalleH
Title :	Chemical composition and biological activities of essential oil of the Malaysian endemic Syzygium variolosum (King) Chantar. & J.Parn
Hits :	37

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains & Matematik
Year of Publication :	2024
Notes :	Natural Product Research
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link
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Abstract : Universiti Pendidikan Sultan Idris

This study was designed to investigate the chemical composition of the essential oil of Syzygium variolosum (King) Chantar. & J.Parn. and their cytotoxicity, acetylcholinesterase, antityrosinase, and anti-inflammatory activities. In total, 32 chemical components were identified in the essential oil, which made up 98.9%. The essential oil is mainly composed of _-elemene (20.2%), bicyclogermacrene (13.5%), viridiflorol (11.1%), globulol (8.6%), and selin-11-en-4_-ol (5.3%). Acetylcholinesterase, antityrosinase, and anti-inflammatory activities were evaluated with the Ellman method, mushroom tyrosinase, and lipoxygenase enzymes, respectively, while cytotoxicity was assessed using an MTT assay. The results showed that essential oil gave significant percentage inhibition (I%: acetylcholinesterase 35.2%, antityrosinase 42.5%, lipoxygenase 48.6%). Furthermore, the essential oil exhibited cytotoxicity against three cancer cell lines, HepG2, MCF7, and A549, with IC50 values ranging from 90.2 to 95.2 _g/mL. The current study highlights the potential of the use of essential oils as an alternative to the development of pharmaceutical antichemopreventives or cosmetics. _ 2024 Informa UK Limited, trading as Taylor & Francis Group.

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