UPSI Digital Repository (UDRep)
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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Triterpenoid is a group of natural products with various remarkable activities, including cytotoxic. One of the sources for this type of compounds is Swietenia genus belong to Meliaceae family. This genus known to contains various secondary metabolites including limonoids, flavonoids, and triterpenoids. Especially for triterpenoid, there is limited report on isolation as well as biological activity from Swietenia genus, such as Swietenia mahagoni. In this research, three triterpenoid compounds have been successively isolated and identified from n-hexane extract, namely, (-)-leucophyllone (1), toonaciliatavarin E (2), and moronic acid (3). All isolated were assed against MCF-7 breast cancer and CV-1 normal kidney cell lines. The result showed that only moronic acid (3) performed moderate activity against two cells with IC50 of 63.10 and 48.04 µM, respectively. The other isolated compounds (1 and 2) showed weak cytotoxicity with IC50 > 500 µM. Based on preliminary structure activity relationship, revealed that pentacyclic triterpenoid (moronic acid, 3) showed stronger cytotoxicity compare with tetracyclic triterpenoids (-)-leucophyllone (1) and toonaciliatavarin E (2). © 2024, Universitas Jenderal Soedirman. All rights reserved. |
| References |
Anderson, J. L. (2015). Mahogany: The costs of luxury inearly America. Harvard University Press, Cambridge, MA. Basak, S.P., Islam, A., & Chakraborty, D.P. (1970). Melianone from Swietenia mahagoni Jacq. Journal of the Indian Chemical Society, 47(5), 501-503. Benosman, A., Richomme, P., Sevenet, T., Perromat, G., Hadi, A. H. A., & Bruneton, J. (1995). Tirucallane triterpenes from the stem bark of Aglaia leucophylla. Phytochemistry, 40(5), 1485–1487. https://doi.org/10.1016/0031-9422(95)00415-4. Cárdenas, P.D., Almeida, A., & Bak, S. (2019). Evolution of structural diversity of triterpenoids. Frontiers in Plant Science, 10, 1523. https://doi.org/10.3389/fpls.2019.01523. Chakraborty, D.P., Basak, S.P., Das, B.C., & Beugelmans, R. (1971). Cyclomahogenol, a new tetracyclic triterpene from Swietenia mahagoni. Phytochemistry, 10(6), 1367-1372. https://doi.org/10.1016/ S0031-9422(00) 84344-7. Chudzik, M., Korzonek-Szlacheta, I., Król, W. (2015). Triterpenes as potentially cytotoxic compounds. Molecules, 20, 1610-1625. https://doi.org/10.3390/molecules20011610. Dharmalingam, K., Tan, B. K., Mahmud, M. Z., Sedek, S. A. M., Majid, M. I. A., Kuah, M. K., & Shu-Chien, A. C. (2012). Swietenia macrophylla extract promotes the ability of Caenorhabditis elegans to survive Pseudomonas aeruginosa infection. Journal of Ethnopharmacology,139 (2), 657-663. https://doi.org/10.1016/j.jep. 2011.12.016. Farabi, K., Harneti, D., Darwati, Mayanti, T., Nurlelasari, Maharani, R., Sari, A. P., Herlina, T., Hidayat, A. T., Supratman, U., Fajriah, S., Azmi, M. N., Shiono, Y. (2022) Dammarane-type triterpenoid from the stem bark of Aglaia elliptica (Meliaceae) and its cytotoxic activities. Molecules, 27, 6757. https://doi.org/ 10.3390/molecules27196757. Hidayat, A.T., Farabi, K., Harneti, D., Maharani, R., Darwati, D., Nurlelasari, N., Mayanti, T., Setiawan, A.S., Supratman, U., and Shiono, Y., 2017, Cytotoxicity and structure activity relationship of dammarane-type triterpenoids from the bark of Aglaia elliptica against P-388 murine leukemia cells, Natural Product Science, 23(4), 291–298. https://doi.org/10.20307/ nps.2017.23.4.29. Heyne, K. 1987. Tumbuhan berguna Indonesia. Terjemahan: Badan Litbang Kehutanan Jakarta. Jilid II dan III. Cetakan kesatu. Jakarta:Yayasan Sarana Wana Jaya. Hill, R. A., & Connolly, J. D. (2020). Triterpenoids. Natural Product Reports, 37(7), 962-998. https://doi.org/10.1039/C9NP000 67. D Janakiram, N. B., Mohammed, A., & Rao, C.V. (2015). Sea cucumbers metabolites as potent anti-cancer agents. Marine Drugs, 13(5), 2909-2923. https://doi.org/10.3390/md130 52909 Lakshminarayana, V., Murty, Y.L.N., & Row L.R. (1981). New triterpenes from Swietenia mahagoni. IV†—the 13C NMR spectra of cycloswietenol, 30-norcycloswietenol and isocycloswietenol. Magnetic Resonance in Chemistry, 17(1), 77-78. https://doi.org/10. 1002/mrc.1270170119. Li, Y., Tang, H., Tian, X., Lin, H., Wang, M., & Yao, M. (2015). Three new cytotoxic isomalabaricane triterpenes from the marine sponge Stelletta tenuis. Fitoterapia, 106, 226-230. https://doi.org/10.1016/j.fitote.2015.09.012. Ludwiczuk, A., Skalicka-Woźniak, K., Georgiev, M.I. (2017). Chapter 11 – Terpenoids. Pharmacognosy, 2017, 233-266. https://doi.org/10.1016/B978-0-12-802104-0.00011-1. Ma, K., Li, L., Bao, L., He, L., Sun, C., Zhou, B., Si, S., & Liu, H. (2015). Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXRβ. Tetrahedron, 71(12), 1808-1814. https://doi.org/10.1016/j.tet.2015.02.002. Meng, D.-l., Xu, L. H., Chen, C., Yan, D., Fang, Z. Z., & Cao, Y. F. (2015). A new resource of hepatic protectant, nor-oleanane triterpenoid saponins from the fruit of Stauntonia brachyanthera. Journal of Functional Foods, 16, 28-39. https://doi.org/10. 1016/j.jff.2015.04.003. |
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