Acetaminophen dopamine and ascorbic acid detection using fluorinated pyrazolone derivative modified multiwalled carbon nanotubes electrochemical sensor

Emi Norzehan Mohamad Mahbob

QR Code Link :
Type :	Thesis
Subject :	Q Science
Main Author :	Emi Norzehan Mohamad Mahbob
Title :	Acetaminophen dopamine and ascorbic acid detection using fluorinated pyrazolone derivative modified multiwalled carbon nanotubes electrochemical sensor
Hits :	2

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2025
Corporate Name :	Perpustakaan Tuanku Bainun
PDF Guest :	Click to view PDF file
PDF Full Text :	Access to this item is restricted as it is published less than 1 year ago.

Abstract : Perpustakaan Tuanku Bainun

This study aims to develop modified multiwalled carbon nanotubes paste electrodes based on pyrazolone derivative ligand for detecting acetaminophen (APAP), dopamine (DOP), and ascorbic acid (AA). 1-Phenyl-3-methyl-4-benzoyl-5-pyrazolone (HPMBP) has been synthesized by mixing of 1-phenyl-3-methyl-5-pyrazolone (PMP) and benzoyl chloride. Second ligand, 1-phenyl-3-methyl-4-(2-fluorobenzoyl)-5-pyrazolone (HPMoFBP) and third ligand, 1-phenyl-3-methyl-4-(3-fluorobenzoyl)-5-pyrazolone (HPMmFBP) have been prepared by mixing of PMP with 2-fluorobenzoyl chloride and 3-fluorobenzoyl chloride separately. To produce the sensor, these ligands are mixed with multiwalled carbon nanotubes and placed in a Teflon tube. The carbon-13 nuclear magnetic resonance (13C NMR) spectrum of HPMBP exhibited chemical shift of 119.20 ppm and 132.01 ppm at the C2_ and C3_ position, respectively. The presence of the fluorine atom deshielded the C2_ of HPMoFBP and C3_ of HPMmFBP to 159.91 ppm and 160.99 ppm, respectively. Under optimum conditions, the HPMBP/MWCNT/CPE (_ES=5 mV, a=60 mV, f=180 Hz) detected APAP in 0.1 M PBS (pH 6.4) in the range of 1.0 _M to 1.0 mM with the detection limit (LOD) of 0.245 _M. The HPMoFBP/MWCNT/CPE (_ES=1 mV, a=150 mV, f=60 Hz) in 0.1 M PBS (pH 8.0) and HPMmFBP/MWCNT/CPE (_ES=6 mV, a=150 mV, f=150 Hz) in 0.1 M PBS (pH 7.0) showed a same linear range between 1.0 _M to 1.0 mM and LOD=0.1 _M for detection of DOP and AA, respectively. The sensors performances were not affected by some organic and inorganic substances. The sensors exhibited excellent recoveries between 90% and 105.3%, respectively. Conclusively, the developed sensors based on pyrazolone derivative ligands demonstrated outstanding sensing performance with high selectivity and sensitivity towards the detection of APAP, DOP, and AA. By implication, the developed sensors can be used as an alternative method for the determination of APAP, DOP, and AA in pharmaceutical formulations and human urine.

This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials.
You may use the digitized material for private study, scholarship, or research.

Back to search page