Ahmed, M., Askar, S., Muheden, K., & Bilal, N. (2024). Enhancing Educational Bray, F.,
Laversanne, M., Weiderpass, E., & Soerjomataram, I. (2021). The ever‐increasing importance of
cancer as a leading cause of premature death worldwide. Cancer, 127(16), 3029– 3030.
Torre, L. A., Bray, F., Siegel, R. L., Ferlay, J., Lortet‐Tieulent, J., & Jemal, A. (2015).
Global cancer statistics, 2012. CA: A Cancer Journal for Clinicians, 65(2), 87–108.
Santandreu, F. M., Valle, A., Oliver, J., & Roca, P. (2011). Resveratrol potentiates the
cytotoxic oxidative stress induced by chemotherapy in human colon cancer cells. Cellular
Physiology and Biochemistry, 28(2), 219–228.
van der Stok, E. P., Spaander, M. C. W., Grünhagen, D. J., Verhoef, C., & Kuipers, E. J.
(2017). Surveillance after curative treatment for colorectal cancer. Nature Reviews Clinical
Oncology, 14(5), 297–315.
Park, S.-Y., Kim, J.-Y., Jang, G.-B., Choi, J.-H., Kim, J.-H., Lee, C.-J., Lee, S., Baek, J.-H.,
Park, K.-K., & Kim, J.-M. (2021). Aberrant activation of the CD45-Wnt signaling axis
promotes stemness and therapy resistance in colorectal cancer cells. Theranostics, 11(18),
8755.
Fernández, J., Redondo-Blanco, S., Gutiérrez-del-Río, I., Miguélez, E. M., Villar, C. J., &
Lombo, F. (2016). Colon microbiota fermentation of dietary prebiotics towards short-chain
fatty acids and their roles as anti-inflammatory and antitumour agents: A review. Journal of
Functional Foods, 25, 511–522.
Pan, M., Lai, C., Wu, J., & Ho, C. (2011). Molecular mechanisms for chemoprevention of
colorectal cancer by natural dietary compounds. Molecular Nutrition & Food Research,
55(1), 32–45.
Housman, G., Byler, S., Heerboth, S., Lapinska, K., Longacre, M., Snyder, N., & Sarkar, S.
(2014). Drug resistance in cancer: an overview. Cancers, 6(3), 1769–1792.
Colussi, D., Brandi, G., Bazzoli, F., & Ricciardiello, L. (2013). Molecular pathways
involved in colorectal cancer: implications for disease behavior and prevention.
International Journal of Molecular Sciences, 14(8), 16365–16385.
Singh, C. K., George, J., & Ahmad, N. (2013). Resveratrol‐based combinatorial strategies
for cancer management. Annals of the New York Academy of Sciences, 1290(1), 113–121.
Amiri, F., Zarnani, A.-H., Zand, H., Koohdani, F., Jeddi-Tehrani, M., & Vafa, M. (2013).
Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular
and colon cancer cell lines. European Journal of Pharmacology, 718(1–3), 34–40.
Fattorusso, E., & Taglialatela-Scafati, O. (2007). Modern alkaloids: structure, isolation,
synthesis, and biology. John Wiley & Sons.
Perucka, I., & Oleszek, W. (2000). Extraction and determination of capsaicinoids in fruit of
hot pepper Capsicum annuum L. by spectrophotometry and high-performance liquid
chromatography. Food Chemistry, 71(2), 287–291.
Koleva-Gudeva, L., Mitrev, S., Maksimova, V., & Spasov, D. (2013a). Content of capsaicin
extracted from hot pepper (Capsicum annuum ssp. microcarpum L.) and its use as an
ecopesticide. Hemijska Industrija, 67(4), 671–675.
Koleva-Gudeva, L., Mitrev, S., Maksimova, V., & Spasov, D. (2013b). Content of
capsaicin extracted from hot pepper (Capsicum annuum ssp. microcarpum L.) and its use
as an ecopesticide. Hemijska Industrija, 67(4), 671–675.
Chen, G., Han, Y., Zhang, H., Tu, W., & Zhang, S. (2021a). Radiotherapy-induced
digestive injury: diagnosis, treatment and mechanisms. Frontiers in Oncology, 11, 757973.
Lomax, M. E., Folkes, L. K., & O’neill, P. (2013). Biological consequences of radiationinduced
DNA damage: relevance to radiotherapy. Clinical Oncology, 25(10), 578–585.
Chen, G., Han, Y., Zhang, H., Tu, W., & Zhang, S. (2021b). Radiotherapy-induced
digestive injury: diagnosis, treatment and mechanisms. Frontiers in Oncology, 11, 757973.
Qu, W., Zhang, L., & Ao, J. (2020). Radiotherapy induces intestinal barrier dysfunction by
inhibiting autophagy. Acs Omega, 5(22), 12955–12963.
Chung, D. M., Kim, J. H., & Kim, J. K. (2015). Evaluation of MTT and Trypan Blue
assays for radiation-induced cell viability test in HepG2 cells. International Journal of
Radiation Research, 13(4), 331.
Shukla, P. K., Gangwar, R., Manda, B., Meena, A. S., Yadav, N., Szabo, E., Balogh, A.,
Lee, S. C., Tigyi, G., & Rao, R. (2016). Rapid disruption of intestinal epithelial tight
junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection
by N-acetyl-l- cysteine. American Journal of Physiology-Gastrointestinal and Liver
Physiology, 310(9), G705–G715.
Suetens, A., Moreels, M., Quintens, R., Soors, E., Buset, J., Chiriotti, S., Tabury, K.,
Gregoire, V., & Baatout, S. (2015). Dose-and time-dependent gene expression alterations
in prostate and colon cancer cells after in vitro exposure to carbon ion and X-irradiation.
Journal of Radiation Research, 56(1), 11–21.
Lee, S.-H., Krisanapun, C., & Baek, S. J. (2010). NSAID-activated gene-1 as a molecular
target for capsaicin-induced apoptosis through a novel molecular mechanism involving
GSK3β, C/EBPβ and ATF3. Carcinogenesis, 31(4), 719–728.
Kim, M. Y., Trudel, L. J., & Wogan, G. N. (2009). Apoptosis induced by capsaicin and
resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation.
Anticancer Research, 29(10), 3733–3740.
Yang, K., Pyo, J., Kim, G.-Y., Yu, R., Han, I., Ju, S., Kim, W., & Kim, B.-S. (2009).
Capsaicin induces apoptosis by generating reactive oxygen species and disrupting
mitochondrial transmembrane potential in human colon cancer cell lines. Cellular and
Molecular Biology Letters, 14(3), 497–510.
Zhang, S., Wang, D., Huang, J., Hu, Y., & Xu, Y. (2020). Application of capsaicin as a
potential new therapeutic drug in human cancers. Journal of Clinical Pharmacy and
Therapeutics, 45(1), 16–28
Hatif, A. R., Abdul Rahman, A., Abdulwahid, T. A., Ahmed, N. M., Mahdi Badi, K.,
Jumaah Mhawes, A., Khaled Albadarneh, L., & Rashid Hatif, A. (2024). Combined
radiotherapy, plant extracts, and chemotherapy in colorectal cancer cells. PQ.