Extraction and isolation of alkaloids from the leaves of Alseodaphne corneri Kosterm

Nafiah Mohd Azlan, Khoo Jennie,Hui Chen, Mohammad Siti Nor Fadzilah, Awang Khalijah, A. Hadi A. Hamid, Ahmad Kartini,

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Type :	article
Subject :	QD Chemistry
Main Author :	Nafiah Mohd Azlan, Khoo Jennie,Hui Chen, Mohammad Siti Nor Fadzilah, Awang Khalijah, A. Hadi A. Hamid, Ahmad Kartini,
Title :	Extraction and isolation of alkaloids from the leaves of Alseodaphne corneri Kosterm

Year of Publication :

2013

Abstract :

The isolation and purification of the leaves extract of Alseodaphne corneri Kosterm yielded four alkaloids; norisocorydine 1, isocorydine 2, 2-norobamegine 3 and obamegine 4. This phytochemical study involves extraction, separation by using various chromatographic methods and structural determination by spectroscopic technique such as ultraviolet spectroscopy (UV), infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR) including 1D-NMR (1H, 13C and DEPT), 2D-NMR (COSY, NOESY, HMQC/HSQC, and HMBC) and mass spectrometry (MS). The IC50 value of antiplasmodial activity for isocorydine 2 and obamegine 4 are 0.50 μmolL-1 and 0.14 μmolL-1 respectively.

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