Synthesis, spectroscopic studies and biological activities of acylthiourea derivatives as potential anti-bacteria agents

- Wan M. Khairul, Ahmad Ariffin Aziah, Ismail Noraznawati, Daud Adibah Izzati,

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Type :	article
Subject :	QD Chemistry
ISSN :	2289-7070
Main Author :	- Wan M. Khairul, Ahmad Ariffin Aziah, Ismail Noraznawati, Daud Adibah Izzati,
Title :	Synthesis, spectroscopic studies and biological activities of acylthiourea derivatives as potential anti-bacteria agents

Place of Production :	Universiti Pendidikan Sultan Idris
Year of Publication :	2016

Abstract :

Thiourea is known to be a unique class of organic compounds especially acylthiourea since they consist excellent Hbonds donor and acceptor where it has strong ability to form metal complexation with various metal salts. Therefore, six members of acylthiourea derivatives (TH1-TH6) have been successfully synthesized and characterised using selected spectroscopic and analytical methods namely Fourier-Transform Infrared (FT-IR) spectroscopy, UV-visible (UV-vis) spectrophotometer, and CHNS elemental analysis. In turn, all the synthesised TH1-TH6 were used to investigate the anti-bacterial activity towards selected bacteria of both Gram-negative and positive namely Salmonella typhi and Bacillus cereus respectively. TH1-TH6 revealed to have good activity towards S. typhi and B. cereus with specific and broad-range spectrum activity.

References

1. Abbasi, J., Yahyazadeh, A., Mamaghani, M., &Rassa, M. (2013). Regioselective synthesis of novel 3-allyl-2- (substituted imino) - (3-substituted-2-imino-4-phenyl-3 H -thiazole) derivatives as antibacterial agents. Journal of Molecular Structure, 1039, 113–118. 2. Abosadiya, H. M., Hasbullah, S. A., & Yamin, B. M. (2015). Synthesis, X-ray, NMR, FT-IR, UV/vis, DFT and TD-DFT studies of N-(4-chlorobutanoyl)-N′-(2-, 3-and 4-methylphenyl) thiourea derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 144, 115-124. 3. Abosadiya, H. M., Hasbullah, S. A., Yamin, B. M., & Fadzil, A. H. (2014).1-(4-Chlorobutanoyl)-3-(3- chlorophenyl) thiourea. Acta Crystallographica Section E: Structure Reports Online, 70(6), o675-o675. 4. Ameram, N., & Yamin, B. M. (2013). Synthesis and Characterization O - , M- and Para -Toluyl Thiourea Substituted Para- Pyridine and Ethyl Pyridine as a Chromoionophore. IOSR Journal of Applied Chemistry 4(6), 59–67. 5. Arslan, H. and Kulcu, N. (2003). Synthesis and characterization of copper (II), nickel (II) complexes with novel thiourea derivatives. Transition Metal Chemistry 28: 816-819. 6. Eweis, M., Elkholy, M.M. & Elsabee, M.Z. 2006. Antifungal efficiency of chitosan and its thiourea derivatives upon the growth of some sugar-beet pathogens. International Journal of Biolgical Macromolecules.38: 1 8. 7. Faidallah, H. M., Khan, K. A., & Asiri, A. M. (2011).Synthesis and biological evaluation of new 3, 5-di (trifluoromethyl)-1, 2, 4-triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents. Journal of Fluorine Chemistry, 132(11), 870-877. 8. Geng, Z. Z., Zhang, J. J., Lin, J., Huang, M. Y., An, L. K., Zhang, H. B., .. & Chen, W. M. (2015). Novel cajaninstilbene acid derivatives as antibacterial agents. European Journal of Medicinal Chemistry, 100, 235- 245. 9. Golan, D. E. Tashjian, A. H., Armstrong, E. J. (2008). Principles of Pharmacology: The Pathophysiologic Basic of Drug Theraphy. 2nd edition, Wolters Kluwer, Lippincott Williams & Wiikings. 10. Hadwiger, L. A., Kendra, D. F., Fristensky, B. W., & Wagoner, W. (1986). Chitosan both activates genes in plants and inhibits RNA synthesis in fungi. In Chitin in nature and technology (pp. 209-214).Springer US. 11. Lv, P. C., Li, H. Q., Sun, J., Zhou, Y., & Zhu, H. L. (2010). Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents. Bioorganic & Medicinal Chemistry, 18(13), 4606- 4614. 12. Pavia, D.L., Lampman, G.M., Kriz, G.S. & Vyvyan, J.R. (2009). Introduction to Spectroscopy.4th Edition. Washington. Brooks/ Cole Thomson Learning. 13. Pete, U. D., Zade, C. M., Bhosale, J. D., Tupe, S. G., Chaudhary, P. M., Dikundwar, A. G., & Bendre, R. S. (2012). Hybrid molecules of carvacrol and benzoyl urea/thiourea with potential applications in agriculture and medicine. Bioorganic & Medicinal Chemistry Letters, 22(17), 5550-5554. 14. Rodriguez-Fernandez, E., Manzano, J. L., Benito, J. J., Hermosa, R., Monte, E., & Criado, J. J. (2005). Thiourea, triazole and thiadiazine compounds and their metal complexes as antifungal agents. Journal of Inorganic Biochemistry, 99(8), 1558-1572. 15. Saeed, A., Shaheen, U., Hameed, A. & Naqvi, S. Z. H. 2009. Synthesis, characterization and antimicrobial activity of some new 1-(fluorobenzoyl)-3- (fluorophenyl) thioureas. Journal of Flourine Chemistry 130: 1028- 1034. 16. Sanabria-Ríos, D. J., Rivera-Torres, Y., Rosario, J., Gutierrez, R., Torres-García, Y., Montano, N., &Carballeira, N. M. (2015). Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. Bioorganic & Medicinal Chemistry Letters, 25(22), 5067-5071. 17. Weiqun, Z., Wen, Y., Liqun, X., Chen, X. (2005). N-Benzoyl-N’-dialkylthiourea derivatives and their Co (iii) complexes: Structure, and antifungal. Journal of Inorganic Biochemistry 99: 1314-1319. 18. Zadrazilova, I., Pospisilova, S., Masarikova, M., Imramovsky, A., Ferriz, J. M., Vinsova, J., & Jampilek, J. (2015). Salicylanilidecarbamates: Promising antibacterial agents with high in vitro activity against methicillinresistant Staphylococcus aureus (MRSA). European Journal of Pharmaceutical Sciences, 77, 197-207.

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