UPSI Digital Repository (UDRep)
|
UPSI Digital Repository (UDRep)
|
|
|
| ||||||||||||||||||
| Abstract : Universiti Pendidikan Sultan Idris |
| Two species from Lauraceae family; Alseodaphne pendulifolia Gamb. (KL 5732) and Alseodaphne peduncularis (Wall. ex Nees) Meisn (KL 5165) were collected from I-Iutan Simpang Lenggor, Mersing, Johor and Kluang-Mersing, Johor, respectively. Phytochemical study on these species involves extraction, separation by using various chromatographic methods and structural elucidation by spectroscopic techniques such as nuclear magnetic resonance (NMR), including I D-NMR (11-1, I3C and DEPT), 2D-NMR (COSY, HMQC/I-ISQC, and I-IMBC). Comparison with previous work were also used in elucidated the compounds structure. Five compounds were successfully isolated from Alseodaphne pendulifolia; norisocorydine N-oxide 22, corydine 23, N-mcthylhernaginc 24, oxohernagine 25 and hernagine 26 and three compounds from Alseodaphne peduncularis; boldine 27, norlirioferine 28, norboldine 29. Preliminary screening on alkaloids crude extract from these species exhibited antiplasmodial activity 0.8041lg/ml ICso and 2.135 ug/ml 1Cso against Plasmodium Jalciparum, K I isolate (resistant strain) for Alseodaphne pendulifolia and Alseodaphne peduncularis, respectively. Further investigations on isolated compounds were found to possess anti plasmodial activity (0.404 - 2.2281lg/ml ICso). Corydine 23 and oxohernagine 25 from Alseodaphne pendulifolia shows the potent results 0.404 ug/ml 1Cso and 0.738 ug/ml ICso, respectively that is active against PlasmodiumJalciparum, K I isolate (resistant strain), while the others compounds arc good to moderate active activity. |
| This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials. You may use the digitized material for private study, scholarship, or research. |