Synthesis of n-alkylated and n-acylated derivatives of girinimbine

Mohd Nor Siti Mariam, Osman Fatin Nurul Atiqah, Ahmad Kartini, Nafiah Mohd Azlan,

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Girinimbine, a carbazole alkaloid has drawn an attention due to its wide range of pharmacological effects such as antiplatelet, antibacterial and anticancer activities. Five new derivatives of girinimbine were successfully semi-synthesized via modification on N-terminal of naturally isolated girinimbine. N-Benzylgirinimbine, N-butylgirinimbine and N-isopentylgirinimbine were obtained from alkylation reaction,whereas, N-butyrylgirinimbine and N- methylbutyrylgirinimbine were obtained from acylation reaction.The structures of synthesized girinimbine derivatives were confirmed by spectroscopic techniques.

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