UPSI Digital Repository (UDRep)
|
UPSI Digital Repository (UDRep)
|
|
|
| ||||||||||||||
| Full Text : |
| A phytochemical study of Alphonsea cylindrica King (unreported) has led to the isolation of six alkaloids. The compounds were identified as kinabaline (1;azafluorenone alkaloid), muniranine (2), O-methylmoschatoline (3; oxoaporphine alkaloid), lysicamine (4), atherospermidine (5) and N methylouregidione (6; 4, 5-dioxoaporphine alkaloid). The structures of the isolated compounds were determined based on the spectroscopic techniques and by comparison with data reported in the literature. Alkaloid 2 was isolated as a new derivative of azafluorenone while alkaloids 1, 3 - 6 were isolated for the first time from Alphonsea species. In addition, alkaloid 3 and 4 showed inhibition zone against Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus in disc diffusion test. The minimum inhibition concentration (MIC) values of lysicamine (4) against S. aureus, B. cereus and P. aeruginosa were found to be smaller than O-methylmoschatoline (3). Therefore, the reported antibacterial activity showed the potential of this plant as natural antibacterial agent and supported the documented traditional use of Alphonsea sp. in the treatment of diarrhea and fever |
| References |
(1) Srivastava,G.; Mehrotra,R. C.PLoS ONE 2013, 8, 1-6.
(2) Turner,I.M. Gard. Bull. Singapore 2009, 61, 185-188.
(3) Latiff, A. Malay. Nat. J. 2013, 65, 247-273.
(
4) Turner, I. M; Utteridge, T. M. A. Blumea 2015, 59, 206-208.
(5) Turner, I. M. Gard. Bull. Singapore 2016, 68, 65-69.
(6) IUCN Red List of Threatened Species. 2010.
(7) Batugal, P. A.; Jayashree, K.; Lee, S. Y.; Jeffrey, T. O. Medicinal Plants Research in Asia, Volume 1: The Framework and Project Workmplans. International Plant Genetic Resources Institute – Regional Office
for Asia; the Pacific and Oceania (IPGRI-APO), Malaysia, 2004, 3-6.
(8) Jalil, J.; Teh, C. H.; Hussain, K.; Jamal, J. A.; Mohamad, H. F.;Muhammad, K. Abstract of International Conference on Natural Products 2015, 154.
(9) Thang, T. D.; Huong, L. T.; Dai, D. N.; Oguwande, I. A. Nat. Prod. Res. 2013, 27, 2022-2026.
(10) Johnson, T. A.; Sohn, J.; Ward, A. E.; Cohen, T. L.; Lorig-Roach, N. D.; Chen, H.; Pilli, R. A.; Widjaja, E. A.; Hanafi, M.; Kardono, L. B. S.; Lotulung, P. D.; Boundy-Mills, K.; Bjeldanes, L. F. Bioorg. Med.
Chem. 2013, 21, 4358-4364.
(11) Xie, N.; Xu, R.; Zhong, S.; Zhao, S. Journal-china Pharmaceutical University, 1994, 25, 205.
(12) Bently, K. W. Nat. Prod. Rep. 2001, 18, 148-170.
(13) Xie, N.; Zhong, S.; Zhao, S.; Peter, G. W. J. China Pharm. Uni. 1989, 20, 321-324.
(14) Yang, N.; Xie, N.; Zhi, F. J. China Pharm. Uni. 1999, 30, 171-173.
(15) Yang, N. Y.; Xie, N.; Kong, L. Y.; Li, G. Chin. Chem. Lett. 2000, 11, 409.
(16) Ning, X.; Yang, N. Y. Chin. Chem. Lett. 1999, 10, 671-672.
(17) Mahanta, P. K.; Mathur, R. K.; Gopinath, K. W. Indian J. Chem. 1975, 13, 306-308.
(18) Tadi , D.; Wanningama, G. P.; Cassels, B. K.; Cavé, A. J. Nat. Prod. 1987, 50, 518-519.
(19) Gopinath, K. W.; Mahanta, P. K.; Bohlmann, F.; Zedro C. Tetrahedron 1976, 32, 737-740
(20) Narendra, P. D. Res. J. Pharmacol. Pharmacodyn. 2009, 1, 66-69.
(21) Horgen, F. D.; Edrada, R. A.; de los Reyes, G.; Agcaoili, F.;Madulid, D. A.; Wongpanich, V.; Angerhofer, C. K.; Pezzuto, J. M.;Soejarto, D. D.; Farnsworth, N. R. Phytomedicine 2001, 8, 71-81.
(22) Indrani, V.; Madhuri, T.; Lakshmi, K. B.; Suvarnalatha, D. P. Int. J. Sci. Res. Management 2015, 3, 2103-2105.
(23) Norhayati, I.; Getha, K.; Haffiz, J. M.; Ilham, A. M.; Sahira, H. L.; Siti Syarifah, M. M.; Syamil, M. A. J. Trop. For. Sci. 2013, 25, 52-59.
(24) Hanum, F. I.; Ibrahim, A. Z.; Khamis, S.; Nazre, M.; Lepun, P.;Rusea, G.; Lajuni, J. J.; Latiff, A. Pertanika J. Trop. Agric. Sci. 2001, 24, 63-78.
(25) Sati, S. C.; Khulbe, K.; Joshi, S. Res. J. Microbiol. 2011, 6, 289-296.
(26) European Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Clin. Microbiol. Infect. 2000, 9, 1-7.
(27) Yusof, H.; Din, L. B.; Yaacob, W. A.; Ibrahim, N.; Yamin, B. M.;Latiff A. Sains Malaysiana 2015, 44, 1125-1128.
(28) Husain, K.; Jamal, J. A.; Jalil, J. Int. J. Pharm. Pharm. Sci. 2012, 4,465-467.
(29) Costa, E. V.; Marques, F. D. A.; Pinheiro, M. L. B.; Braga, R. M.; Delarmelina, C.; Duarte, M. C. T.; Ruiz, A. L. T. G.; V; de Carvalho, J. E.; Maia. B. H. J. Braz. Chem. Soc. 2011, 22, 1111-1117.
(30) Wirasathien, L.; Boonarkart, C.; Pengsuparp, T.; Suttisri, R. Pharm. Biol. 2006, 44, 274-278.
(31) Tadi , D.; Cassels, B. K.; Leboeuf, M.; Cavé, A. Phytochemistry 1987, 26, 537-541.
(32) Yoshida, N. C.; de Siqueira, J. M.; Rodrigues, R. P.; Correia, R. P.; Garcez, W. S. J. Braz. Chem. Soc. 2013, 24, 529-533.
(33) Tadi , D.; Cassels, B. K.; Cavé, A. Heterocycles 1988, 27, 407-421.
(34) Tan, K. K.; Khoo, T. J.; Rajagopal, M.; Wiart, C. Nat. Prod. Res. 2015, 29, 2346-2349.
(35) Omar, H.; Hashim, N. M.; Zajmi, A.; Nordin, N.; Abdelwahab, S.I.; Azizan, A. H.; Hadi, A. H; Ali, H. M. Molecules 2013, 18, 8994-9009.
(36) Tavares Lde, C.; Zanon, G.; Weber, A. D.; Neto, A. T.; Mostardeiro, C. P.; Da Cruz, I. B.; Oliveira, R. M.; Ilha, V.; Dalcol, I. I.; Morel, A. F. PLoS One 2014, 9, e97000. |
| This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials. You may use the digitized material for private study, scholarship, or research. |