Alkaloids from cryptocarya densiflora blume (lauraceae) and their cholinesterase inhibitory activity

Wan Othman Wan Nurul Nazneem, Sivasothy Yasodha, Liew Sook Yee, Mohamad Jamaludin, Nafiah Mohd Azlan, Ahmad Kartini, Litaudon Marc,

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Type :	article
Subject :	Q Science (General)
ISSN :	1874-3900
Main Author :	Wan Othman Wan Nurul Nazneem, Sivasothy Yasodha, Liew Sook Yee, Mohamad Jamaludin, Nafiah Mohd Azlan, Ahmad Kartini, Litaudon Marc,
Title :	Alkaloids from cryptocarya densiflora blume (lauraceae) and their cholinesterase inhibitory activity

Year of Publication :

2017

Full Text :

(−)-Desmethylsecoantofine N-oxide (1), a new seco-phenanthroindolizidine alkaloid along with prodensiflorins A and B (2-3), two new proaporphine alkaloids, were isolated from the leaves of Cryptocarya densiflora Blume. Their structures were established on the basis of 1D and 2D NMR techniques and LCMS-IT-TOF analysis. (+)-Nmethyllaurotetanine (4), (+)-laurotetanine (5), (+)-nornantenine (6), crychine (7), (−)-isocaryachine (8), (+)-reticuline (9), (−)-desmethylsecoantofine (10), (+)-oridine (11), dicentrinone (12) and (−)-antofine (13) were also isolated with compounds 4, 7–9 and 12–13 being characterized for the first time in this plant. Compounds 1-3 were moderate to weak AChE and BChE inhibitors while compound 10 was a DPPH free radical scavenger.

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