Terpenes and phenolic compounds of Murraya Koenigii

Siow-Ping, Tan

Abstract

Murraya koenigii (L.) Spreng, an evergreen plant, is mostly distributed in tropical and subtropical regions [1]. It belongs to the Murraya genus of the Rutaceae family, which is widely grown in home gardens in Malaysia for its aromatic leaves and as one of the important ingredients in Indian cuisine. Previous phytochemical studies on M. koenigii revealed the presence of carbazole alkaloids [2–7] and coumarins [8]. Herein, we present data on the isolation and identification of three triterpenes and two phenolic compounds from the hexane crude extracts of the bark and leaves of M. koenigii collected from Pahang, Malaysia. The hexane crude extract of the bark (30.0 g) was chromatographed over silica gel 60F254 (70–230 mesh) and extensively subjected to silica gel 60F254 (230–400 mesh) column chromatography and preparative TLC on silica gel GF254, leading to the isolation of compounds 1–3, and 5. Meanwhile, compounds 1, 4, and 6 were isolated from the leaves hexane extract (20.0 g) of M. koenigii.

References

1. L. Wei, Y. Z. Wang, Z. Y. Li, Plant Biol., 14 (1), 190 (2012) 2. S. Nakamura, S. Nakashima, Y. Oda, N. Yokota, K. Fujimoto, T. Matsumoto, T. Ohta, K. Ogawa, S. Maeda, S. Nishida, H. Matsuda, M. Yoshikawa, Bioorg. Med. Chem., 21 (5), 1043 (2013) 3. C. Ito, Y. Thoyama, M. Omura, I. Kajiura, H. Furukawa, Chem. Pharm. Bull., 41 (12), 2096 (1993) 4. Q. Ma, J. Tian, J. Yang, A. Wang, T. Ji, Y. Wang, Y. Su, Fitoterapia, 87, 1 (2013) 5. K. Ahmad, S. P. Tan, M. A. Sukari, A. M. Ali, M. A. Nafiah, Am. J. Plant Sci., 5 (19), 2869 (2014) 6. S. P. Tan, M. A. Ali, M. A. Nafiah, K. Awang, K. Ahmad, Tetrahedron, 71, 3946 (2015) 7. C. Tantapakul, W. Phakhodee, S. Laphookhioe, T. Ritthiwigrom, S. Cheenpracha, Chem. Nat. Compd., 50 (1), 186 (2014) 8. C. A. Adebajo, J. Reisch, Fitoterapia, 71, 334 (2000) 9. D. Borchman, M. C. Yappert, S. E. Milliner, R. J. Smith, R. Bhola, Lipids, 48 (12), 1269 (2013) 10. S. Ivanova, V. Tonchev, N. Yokoi, M. C. Yappert, D., G. As. Georgiev, Int. J. Mol. Sci., 16, 21813 (2015) 11. V. S. P.Chaturvedula, I. Prakasu, Int. Curr. Pharm. J., 1 (9), 239 (2012) 12. A. Barla, H. Birman, S. Kultur, S. Oksuz, Turkey J. Chem., 30, 325 (2006) 13. C. S. Chanotiya, S. S. Sammal, C. S. Mathela, Indian J. Chem., 44B, 1922 (2005) 14. M. S. M. Rawat, V. Shukla, S. Negi, G. Pant, Indian J. Chem.,45B, 2566 (2006) 15. M. Matsuo, S. Urano, Tetrahedron, 32, 229 (1976)