Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum miq

Wan Mohd Nuzul Hakimi Wan Salleh

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Type :	article
Subject :	Q Science
Main Author :	Wan Mohd Nuzul Hakimi Wan Salleh
Additional Authors :	Nur Athirah Hashim Shamsul Khamis
Title :	Chemical constituents and lipoxygenase inhibitory activity of Piper stylosum miq

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2019
Corporate Name :	Universiti Pendidikan Sultan Idris

Abstract : Universiti Pendidikan Sultan Idris

Chemical constituents and lipoxygenase inhibitory activity of the aerial part of Piper stylosum have been studied. Fractionation and purification of the extracts afforded five lignans, identified as yangambin (1), sesamin (2), syringaresinol (3), pinoresinol (4), and medioresinol (5), together with other constituents; 4-allyl resorcinol, β-sitosterol, β-sitostenone, taraxerol, vanilin, and vanilic acid. The structures of these compounds were established by analysis of their spectral data, as compared to that of reported compounds. The lipoxygenase inhibitory activity of the extracts and isolated lignans were also evaluated

References

1. Cheng, Y.; Xia N.; Gilbert, M.G. Piperaceae. Flora of China, Vol. 4, Science Press: Beijing, China; 1999; pp. 110-129.

2. Debebe, E.; Dessalegn, T.; Melaku, Y. Chemical constituents and antioxidant activities of the fruits extracts of Piper capense. Bull. Chem. Soc. Ethiop. 2018, 32, 167-174.

3. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y. Chemical compositions and antimicrobial activity of the essential oils of Piper abbreviatum, P. erecticaule and P. lanatum (Piperaceae). Nat. Prod. Commun. 2014, 9, 1795-1798.

4. Burkill, H.I. A Dictionary of Economic Products of the Malay Peninsula, Vol. 2, Ministry of Agricultureand Co-operative: Kuala Lumpur, Malaysia; 1966; pp. 1772-1773.

5. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y. Chemical composition of Piper stylosum Miq. And Piper ribesioides Wall. essential oils and their antioxidant, antimicrobial and tyrosinase inhibition activities. Bol. Latinoam. Caribe Plantas Med. Aromat. 2014, 13, 488-497.

6. Salleh, W.M.N.H.W.; Hashim, N.A.; Ahmad, F.; Khong, H.Y. Anticholinesterase and antityrosinase activities of ten Piper species from Malaysia. Adv. Pharm. Bull. 2014, 4, 527-531.

7. Salleh, W.M.N.H.W.; Kamil, F.; Ahmad, F.; Sirat, H.M. Antioxidant and anti-inflammatory activities of essential oil and extracts of Piper miniatum. Nat. Prod. Commun. 2015, 10, 2005-2008.

8. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y.; Zulkifli, R.M. Comparative study of the essential oils of three Beilschmiedia species and their biological activities. Int. J. Food Sci. Technol. 2016, 51, 240-249.

9. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y.; Zulkifli, R.M. Chemical compositions and biological activities of essential oils of Beilschmiedia glabra. Nat. Prod. Commun. 2015, 10, 1297-1300.

10. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y.; Zulkifli, R.M. Anticholinesterase and antiinflammatory constituents from Beilschmiedia pulverulenta Kosterm. Nat. Prod. Sci. 2016, 22, 225-230.

11. Yan-Ni, S.; Yi-Ming, S.; Lian, Y.; Xing-Cong, L.; Jin-Hua, Z.; Yan, Q.; Hong-Tao, Z.; Dong, W.; Rong-Rong, C.; Chong-Ren, Y.; Min, X.; Ying-Jun, Z. Lignans and aromatic glycosides from Piper wallichii and their antithrombotic activities. J. Ethnopharmacol. 2015, 162, 87-96.

12. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y. Antioxidant and anti-tyrosinase activities from Piper officinarum C. DC (Piperaceae). J. Appl. Pharm. Sci. 2014, 4, 87-91.

13. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y.; Zulkifli, R.M. Chemical constituents and bioactivities from the leaves of Beilschmiedia glabra Kosterm (Lauraceae). Marmara Pharm. J. 2016, 20, 400-406.

14. Salleh, W.M.N.H.W.; Ahmad, F.; Khong, H.Y.; Zulkifli, R.M.; Sarker, S.D. Madangones A and B: Two new neolignans from the stem bark of Beilschmiedia madang and their bioactivities. Phytochem. Lett. 2016, 15, 168-173.

15. Liu, T.; Liang, Q.; Zhang, X.M.; Huang, S.Y.; Xu, W.H. A new furofuranlignan from Piper terminaliflorum Tseng. Nat. Prod. Res. 2018, 32, 335-340.

16. Liu, T.; Liang, Q.; Zhang, X.M.; Li, G.Q.; Xu, B.; Xu, W.H. Chemical constituents from Piper boehmeriifolium (Miq.) Wall. ex C.DC. Biochem. Syst. Ecol. 2017, 75, 27-30.

17. Parreira, R.L.T.; Costa, E.S.; Heleno, V.C.G.; Magalhaes, L.G.; Souza, J.M.; Pauletti, P.M.; Cunha, W.R.; Januario, A.H.; Símaro, G.V.; Bastos, J.K.; Laurentiz, R.S.; Kar, T.; Caramori, G.F.; Kawano, D.F.; Andrade, E.S.M.L. Evaluation of lignans from Piper cubeba against Schistosoma mansoni adult worms: A combined experimental and theoretical study. Chem. Biodivers. 2019, 16, e1800305.

18. Godoy de Lima, R.; Barros, M.T.; da Silva Laurentiz, R. Medicinal attributes of Lignans extracted from Piper cubeba: Current developments. Chemistry Open 2018, 7, 180-191.

19. Benevides, P.J.C.; Sartorelli, P.; Kato, M.J. Phenylpropanoids and neolignans from Piper regnellii. Phytochemistry 1999, 52, 339-343.

20. Moreira, D.; Kaplan, M.A.C.; Guimaraes, E.F. Chemical constituents from Piper solmsianum C. DC. (Piperaceae). Rev. Bras. Farm. 1995, 76, 106-109.

21. Prasad, A.K.; Tyagi, O.D.; Wengel, J.; Boll, P.M. Lignan and neolignan from stem and fruits of Piper wightii. Tetrahedron 1994, 50, 2231-2240.

22. Prasad, A.K.; Tyagi, O.D.; Wengel, J.; Olsen, P.M.; Bisht, K.S.; Singh, A.; Saranji, A.; Kumer, R.; Jain, S.C.; Parmar, V.S. Neolignan and a lignan from Piper clarkii. Phytochemistry 1995, 39, 655-658.

23. Apers, A.; Vlietinck, A.; Pieters, L. Lignans and neolignans as lead compounds. Phytochem. Rev. 2003, 2, 201-217.

24. Wisastra, R.; Dekker, F.J. Inflammation, cancer and oxidative lipoxygenase activity are intimately linked. Cancers (Basel) 2014, 6, 1500-1521.

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