A new xanthone dimer and cytotoxicity from the stem bark  of Calophyllum canum

Muhammad Taher

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Type :	article
Subject :	Q Science (General)
Main Author :	Muhammad Taher
Additional Authors :	Wan Mohd Nuzul Hakimi Wan Salleh Alkhamaiseh, Suhaib Ibrahim Farediah Ahmad Mohamad Fazlin Rezali Deny, Susanti Hasan, Choudhury Mahmood
Title :	A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum

Place of Production :	Tanjong Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2020
Corporate Name :	Universiti Pendidikan Sultan Idris

Abstract : Universiti Pendidikan Sultan Idris

A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), tra-pezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spec-troscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1-3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC 50 > 50 μM).

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