UPSI Digital Repository (UDRep)
|
UPSI Digital Repository (UDRep)
|
|
|
| ||||||||||||||||||||
| Abstract : Universiti Pendidikan Sultan Idris |
| The present study investigates the antioxidant, α-glucosidases, and anti-inflammatory properties of leaf extract of Cassia singueana and C. sieberiana. Cassia singueana and C. sieberiana are restorative plants utilised for the treatment of diabetes, ulcer, malaria, and wound healing. The extracts were evaluated for antioxidant activities via DPPH radical scavenging, ABTS+ radical cation scavenging, FRAP, β-carotene bleaching, phenolic content, and flavonoid content. Meanwhile, α-glucosidases and anti-inflammatory properties were also evaluated against α-glucosidase enzyme and 15-LOX inhibitory activities. The results for C. singueana extract revealed potent activities for DPPH (IC50: 9.35 µg/mL), phenolic contents (120.01 mg GAE/g dry extract), and α-glucosidases inhibition (I%: 90.47%). On the other hand, the findings for C. sieberiana recorded significant activities for FRAP (2120 µmol Fe2+/g dry extract) and 15-LOX inhibition (I%: 80.93%). The extract of C. singueana and C. sieberiana contain possible antioxidant, α-glucosidases, and anti-inflammatory agents that are responsible for the popular use of these plants in the treatment of diabetes and ulcer |
| References |
Abdulrazak N., Asiya U.I., Usman N.S., Unata I.M., Farida A. (2015). Anti-plasmodial activity of ethanolic extract of root and stem back of Cassia sieberiana DC on mice. J Intercult Ethnopharmacol 4: 96-101. Aminudin N.I., Ahmad F., Taher M., Zulkifli R.M. (2015). α-Glucosidase and 15-lipoxygenase inhibitory activities of phytochemicals from Calophyllum symingtonianum. Nat Prod Commun 10(9): 1585-1587. Aruoma O.I., Grootveld M., Bahorun T. (2006). Free radicals in biology and medicine: from inflammation to biotechnology. BioFactors 27:1-3. Bello H., Mohammed Z., Katsayal U.A. (2016). Pharmacognostic evaluation of the root Cassia sieberiana D.C: A promising ethnomedicinal plant. J Pharmacogn Phytochem 5: 270-275. Benzie I.F.F., Strain J.J. (1996). The ferric reducing ability of plasma as a measure of antioxidant power the FRAP assay. Anal Biochem 239(1): 70-76. Biswas R., Mukherjee P.K., Kar A., Bahadur S., Harwansh R.K., Biswas S., Al-Dhabi N.A., Duraipandiyan V. (2016). Evaluation of Ubtan-A traditional indian skin care formulation. J Ethnopharmacol 192: 283-291. Cai Y., Luo Q., Sun M., Corke H. (2004). Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 74: 2157-2184. Cai Y.Z., Mei S., Jie X., Luo Q., Corke H. (2006). Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci 78: 2872-2888. Clarke G., Ting K., Wiart C., Fry J. (2003). High Correlation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing activity potential and total phenolics content indicates redundancy in use of all three assays to screen for antioxidant activity of extracts of plants from the Malaysian rainforest. Antioxidants 2(1): 1-10. Durackova Z. (2010). Some current insights into oxidative stress. Physiol Res 59: 459-469. El?Guendouz S., Aazza S., Lyoussi B., Antunes M.D., Faleiro M.L., Miguel M.G. (2016). Anti?acetylcholinesterase, antidiabetic, anti?inflammatory, antityrosinase and antixanthine oxidase activities of Moroccan propolis. Int J Food Sci Tech 51: 1762-1773. Gideon K.M., Samuel O.O., Maxwell I.E. (2015). Antioxidant and hepatoprotective activity of methanolic extract of Cassia sieberiana leaves in carbon tetrachloride-induced hepatotoxicity in rats. J Adv Med Pharm Sci 2: 1-9. Goossens V., De Vos K., Vercammen D. (2009). Redox regulation of TNF signaling. BioFactors 10: 145-156. Huang D., Ou B., Prior R.L. (2005). The chemistry behind antioxidant capacity assays. J Agric Food Chem 53: 1841-1856. Ifeanyi I.M., Ode O.J. (2012). In vitro and in vivo antioxidant potential of the methanolic extract of Cassia singueana Delile (Fabaceae) Lock leaves. Comp Clin Pathol 21: 1565-1569. Jibril S., Sirat H.M., Basar N. (2017a). Bioassay-guided isolation of antioxidants and α-glucosidase inhibitors from the root of Cassia sieberiana D.C. (Fabaceae). Rec Nat Prod 11: 406-410. Jibril S., Sirat H.M., Basar N. (2017b). A new stilbene from the root of Cassia sieberiana D.C. (Fabaceae). Nat Prod Commun 12(7): 1095-1098. Kelechi M.G., Favour O.O. (2015). Studies on anti-diarrheal activity of Cassia sieberiana in mice. J Adv Biol Biotech 3(4): 139-144. Lee S.Y., Mediani A., Nur Ashikin A.H., Azliana A.B.S., Abas F. (2014). Antioxidant and α-glucosidase inhibitory activities of the leaf and stem of selected traditional medicinal plants. Int Food Res J 21: 165-172. Ode O.J., Asuzu I.U. (2014). Luteolin isolate from the methanol extract identified as the single-carbon compound responsible for broad antiulcer activities of Cassia singueana leaves. IOSR J Pharm 4: 17-23. Ogino K., Wang D.H. (2007). Biomarkers of oxidative/nitrosative stress: an approach to disease prevention. Acta Med Okayama 61: 181-189. Onakpa M.M., Ode O.J. (2010). Evaluation of Cassia singueana extract on stomach HCl production and gastric emptying in rats. Int J Appl Biol Pharm Technol 1: 1352-1358. Prabhakar O. (2013). Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats. NaunynSchmiedeberg's Arch Pharmacol 386: 705-710. Reagan L.P., Magarinos A.M., McEwen B.S. (1999). Neurological changes induced by stress in streptozotocin diabetic rats. Annals New York Acad Sci 893: 126-137. Saidu J., Adoum O.A., Mukhtar M.D. (2011). Screening of Cassia singuaena, Commiphora kerstingii, Khaya senegalensis for brine shrimp lethality and antiplasmodium activity. Chemsearch 2: 50-52. Salleh W.M.N.H.W., Kamil F., Ahmad F., Sirat H.M. (2015a). Antioxidant and anti-inflammatory activities of essential oil and extracts of Piper miniatum. Nat Prod Commun 10(11): 2005-2008. Salleh W.M.N.H.W., Ahmad F., Khong H.Y. (2015b). Evaluation of antioxidant, anticholinesterase and antityrosinase activities of five Cinnamomum species. Dhaka Univ J Pharm Sci 14(2): 125-132. Salleh W.M.N.H.W., Ahmad F., Khong H.Y. (2015c). Antioxidant and anticholinesterase activities of essential oils of Cinnamomum griffithii and C. macrocarpum. Nat Prod Commun 10(8): 1465-1468. Salleh W.M.N.H.W., Ahmad F. (2016). Preliminary investigations of antioxidant, antityrosinase, acetylcholinesterase and antiinflammatory activities of Actinodaphne species. Marmara Pharm J 20(2): 137-143. Salleh W.M.N.H.W., Ahmad F., Khong H.Y., Zulkifli R.M. (2016a). Comparative study of the essential oils of three Beilschmiedia species and their biological activities. Int J Food Sci Tech 51: 240-249. Salleh W.M.N.H.W., Ahmad F., Khong H.Y., Zulkifli R.M. (2016b). Anticholinesterase and anti-inflammatory constituents from Beilschmiedia pulverulenta Kosterm. Nat Prod Sci 22(4): 225-230. Salzanoa S., Checconia P., Hanschmannc E.M. (2014). Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proceeding of National Academy of Sciences of United States of America, p. 12157-12162. Schmelzer G.H., Gurib-Fakim A. (2008). Plant Resource of Tropical Africa 11 (1) Medicinal Plants 1. PROTA Foundation, Wageningen, Netherlands/ Backhuys Publishers, Leiden, Netherlands/CTA, Wageningen, Netherlands. Schneider I., Bucar F. (2005). Lipoxygenase inhibitors from natural plant sources. Part 2: medicinal plants with inhibitory activity on arachidonate 12?lipoxygenase, 15?lipoxygenase and leukotriene hahidul Islam M., Mohammed A. (2017). Anti-diabetic effects of the acetone fraction of Senna singueana stem (Fabaceae). Nat Prod Commun 12: 1095-1098. Shaveta A., Singh M.K., Sharma S., Bhatti R., Singh P. (2014). Rational design, synthesis and evaluation of chromone-indole and chromonepyrazole based conjugates: Identification of a lead for antiinflammatory drug. European J Med Chem 77: 185-192. Stephanie D.E., Xavier V., Philippe C., Arion W., Jean-Michel M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC Assays. J Agric Food Chem 57: 1768-1774. Wu H.R., Zhang W., Pang X.Y., Gong Y., Obulqasim X.M.U., Li H.F., Zhu Y. (2015). Quinones and coumarins from Ajania salicifolia and their radical scavenging and cytotoxic activity. J Asian Nat Prod Res 17: 1196-1203. Yin T.P., Cai L., Xing Y., Yu J., Li X.J., Mei R.F., Ding Z.T. (2016). Alkaloids with antioxidant activities from Aconitum handelianum. J Asian Nat Prod Res 18: 603-610. Zhi-Gang T., Cai L., Dai L., Wei-Jun S., Wei Z., Ya-Bi Y., Qiu E.C., ZhongTao D. (2010). Antioxidant activities of Caragana sinica flower extracts and their main chemical constituents. Molecules 15: 6722-6732.
|
| This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials. You may use the digitized material for private study, scholarship, or research. |