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UPSI Digital Repository (UDRep)
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| Abstract : Universiti Pendidikan Sultan Idris |
| Neuronal survivability is fundamental for optimum cognitive performance, thus human
wellbeing. This study aimed to investigate the effect of Morus nigra, vitamin E, and exercise
neuroplasticity-related biomarkers. Participants (n=40) were randomly assigned to receive Morus
nigra fruit extract, sunflower seed, and pumpkin seed with or without exercise for 60 days. To
obtained serum, blood samples were collected from all participants at the end of the experimental
duration. The serum was used to determine malondialdehyde (MDA), glucocorticoid receptor-α
(GCR-α), glutamate dehydrogenase (GDH), and Brain-Derived Neurotrophic Factor (BDNF)
concentrations using ELISA kit. Compared to the control group, GCR-α was significantly
reduced in all groups, while BDNF concentration was doubled in treatment and exercise group.
GDH concentration was increased significantly in the treatment group. Overall, the findings of
the present study demonstrate that consumption of Morus nigra fruit extract, sunflower seeds,
and pumpkin seeds with or without exercise have neuroprotective effects through enhancing the
production of neuroplasticity marker, and reduced stress hormone. |
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