A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum

Muhammad Taher

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Type :	article
Subject :	Q Science
ISSN :	0939-5075
Main Author :	Muhammad Taher
Additional Authors :	Wan Mohd Nuzul Hakimi Wan Salleh
Title :	A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum

Place of Production :	Tanjung Malim
Publisher :	Fakulti Sains dan Matematik
Year of Publication :	2021
Notes :	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Corporate Name :	Universiti Pendidikan Sultan Idris
HTTP Link :	Click to view web link

Abstract : Universiti Pendidikan Sultan Idris

A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1-3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC50 > 50 ?m). 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.

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