UPSI Digital Repository (UDRep)
|
UPSI Digital Repository (UDRep)
|
|
|
| ||||||||||||||||||||||||
| Abstract : Universiti Pendidikan Sultan Idris |
| This study was aimed to investigate the chemical compositions and lipoxygenase inhibitory activity of the essential oil extracted from Alstonia angustiloba growing in Malaysia. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography and gas chromatography-mass spectrometry methods. Analysis of the A. angustiloba essential oil resulted in the identification of twenty-five chemical components, which constitute 90.8% of the total oil. The most abundant components of A. angustiloba oil were linalool (21.2%), 1,8-cineole (16.8%), ?-terpineol (9.5%), terpinen-4-ol (8.5%), ?-caryophyllene (6.2%), and caryophyllene oxide (5.2%). The essential oil displayed moderate activity towards lipoxygenase inhibitory activity with an IC50 value of 45.8 ?g/mL ? 2021,Chemistry Journal of Moldova.All Rights Reserved |
| References |
Abinaya, M., & Gayathri, M. (2018). Phytochemical screening, in vitro antibacterial and antibiofilm activities of alstonia scholaris leaf extract against several biofilm-forming bacteria. Research Journal of Biotechnology, 13(8), 90-101. Retrieved from www.scopus.com Adams, R. P. (1995). Identification of Essential Oil Components by Gas Chromatography/Mass Spectroscopy, Retrieved from www.scopus.com Adeyemi, M. M., Habila, J. D., Enemakwu, T. A., Okeniyi, S. O., & Salihu, L. (2019). Antimalarial activity of leaf extract, fractions and isolation of sterol from alstonia boonei. Tropical Journal of Natural Product Research, 3(7), 221-224. doi:10.26538/tjnpr/v3i7.1 Burkill, I. H. (1936). A dictionary of the economic products of the malay peninsula. Nature, 137 Retrieved from www.scopus.com Cathcart, M. K., & Folcik, V. A. (2000). Lipoxygenases and atherosclerosis: Protection versus pathogenesis. Free Radical Biology and Medicine, 28(12), 1726-1734. doi:10.1016/S0891-5849(00)00230-6 Cimanga, R. K., Nsaka, S. L., Tshodi, M. E., Mbamu, B. M., Kikweta, C. M., Makila, F. B. -., . . . Pieters, L. (2019). In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of alstonia congensis root bark. Journal of Ethnopharmacology, 242 doi:10.1016/j.jep.2019.02.019 D’Cruz, K. J., & Ambatkar, M. V. (2016). Extraction and qualitative analysis of floral volatiles of alstonia scholaris. Journal of Biological Sciences, 2(3), 17-27. Retrieved from www.scopus.com Dung, N. X., Ngoc, P. H., Rang, D. D., Nhan, N. T., Klinkby, N., & Leclercq, P. (2001). Chemical composition of the volatile concentrate from the flowers of vietnamese alstonia scholaris (L.) R.br., apocynaceae. Journal of Essential Oil Research, 13(6), 424-426. doi:10.1080/10412905.2001.9699714 Hui, T., Sun, Y., Zhu, L., Guo, W., & Rao, G. (2009). Flavonoids in leaves of alstonia scholaris. Zhongguo Zhongyao Zazhi, 34(9), 1111-1113. Retrieved from www.scopus.com Kaushik, P., Kaushik, D., Sharma, N., & Rana, A. C. (2011). Alstonia scholaris: It's phytochemistry and pharmacology. Chron Young Sci, 2(2), 71-78. Retrieved from www.scopus.com Madhiri, R., & Vijayalakshmi, G. (2018). A review on phytochemical composition and pharmacological aspects of the genus alstonia. Pharma Tutor, 6(1), 50-55. Retrieved from www.scopus.com Monachino, J. (1949). A revision of the genus alstonia (apocynaceae). Pacific Sci., 3, 133-182. Retrieved from www.scopus.com Oyebode, O. A., Erukainure, O. L., Ibeji, C. U., Koorbanally, N. A., & Islam, M. S. (2019). Phytochemical constituents, antioxidant and antidiabetic activities of different extracts of the leaves, stem and root barks of alstonia boonei: An in vitro and in silico study. Botany Letters, 166(4), 444-456. doi:10.1080/23818107.2019.1624980 Salleh, W. M. N. H. W., Ahmad, F., Khong, H. Y., & Mohamed Zulkifli, R. (2016). Comparative study of the essential oils of three beilschmiedia species and their biological activities. International Journal of Food Science and Technology, 51(1), 240-249. doi:10.1111/ijfs.12962 Salleha, W. M. N. H. W., Ahmada, F., & Yenb, K. H. (2014). Chemical compositions and antimicrobial activity of the essential oils of piper abbreviatum, P. erecticaule and P. lanatum (piperaceae). Natural Product Communications, 9(12), 1795-1798. Retrieved from www.scopus.com Siddiqui, S. A., Rahman, M. O., Akbar, M. A., Ro uf, A. S. S., Islam, R., Rahman, M. S., & Rahman, A. (2015). Antioxidant and cytotoxic properties of essential oil and various extracts of alstonia scholaris (L.) R.br. Journal of Characterization and Development of Novel Materials, 7(1), 50-61. Retrieved from www.scopus.com Sultana, N., Qazi, M. S., & Kamal, M. (2020). New anti-inflammatory triterpene esters and glycosides from alstonia scholaris. Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 19(4), 370-386. doi:10.2174/1871523018666190724122406 Wong, S. K., Lim, Y. Y., Abdullah, N. R., & Nordin, F. J. (2011). Antiproliferative and phytochemical analyses of leaf extracts of ten apocynaceae species. Pharmacognosy Research, 3(2), 100-106. doi:10.4103/0974-8490.81957 Wong, S. K., Lim, Y. Y., Ling, S. K., & Chan, E. W. C. (2014). Caffeoylquinic acids in leaves of selected apocynaceae species: Their isolation and content. Pharmacognosy Research, 6(1), 67-72. doi:10.4103/0974-8490.122921 Yeo, H. C. H., & Shibamoto, T. (1992). Formation of formaldehyde and malonaldehyde by photooxidation of squalene. Lipids, 27(1), 50-53. doi:10.1007/BF02537059 Zhao, Y. -., Yang, Z. -., Wu, B. -., Shang, J. -., Liu, Y. -., Wang, X. -., & Luo, X. -. (2020). Indole alkaloids from leaves of alstonia scholaris (L.) R. br. protect against emphysema in mice. Journal of Ethnopharmacology, 259 doi:10.1016/j.jep.2020.112949 |
| This material may be protected under Copyright Act which governs the making of photocopies or reproductions of copyrighted materials. You may use the digitized material for private study, scholarship, or research. |