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Type :article
Subject :QD Chemistry
ISSN :0974-3618
Main Author :Hamidah Idris
Additional Authors :Majhool, Ali Arkan
Wan Mohd Nuzul Hakimi W Salleh
Title :Chemical compounds and antimicrobial activities of actinomycetes isolates from BRIS soil
Place of Production :Tanjung Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2021
Notes :Research Journal of Pharmacy and Technology
Corporate Name :Universiti Pendidikan Sultan Idris
Web Link :Click to view web link

Abstract : Universiti Pendidikan Sultan Idris
The existing study examined three actinomycetes isolated from Beach Ridges Interspersed with Swales (BRIS) soil where the morphological properties were examined and chemical compounds of their metabolite extracts were ana; ysed. Based on phylogenetic analysis of 16S rRNA gene sequences, the strains were identified as Streptomyces sp. AA13, Amycolatopsis sp. AA12 and Micromonosporasp. AA141. Antimicrobial activities of the extracts were tested against a panel of microorganisms that consist of Escherichia coli DSM 30083, Bacillus subtilis DSM 10, Pseudomonas fluorescens DSM 50090, Klebsiella pneumoniae DSM 30104, Micrococcus luteus DSM 20030, and Saccharomyces cerevisiae. Results revealed a wide range of antimicrobial activities produced by the isolates at different concentration of each extracts. The extracts were found to show stronger antimicrobial activities against gram-negative bacteria compared to gram-positive bacteria, while no activities were shown when tested against fungi. Thirty-nine compounds were detected both from Streptomycessp. AA13 and Amycolatopsissp. AA12, while thirty-eight compounds from Micromonosporasp. AA141 using GC-MS. This Study Demonstrate the ability of actinomycetes in producing variety type of compounds with antimicrobial activities that may be the potential candidates as drug leads. ? RJPT All right reserved.


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