UPSI Digital Repository (UDRep)
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Abstract : Universiti Pendidikan Sultan Idris |
The transmission of viral hepatitis type B (HBV) is of significant public health concern. The infection result depends on how well the virus interacts with the host and in particular, on the ability to respond inherently and adaptively to the humoral and cellular immunity. The purpose of this study is to evaluate clinical, immunology and tracer status (viral). This study showed the relationship between the immune and chronic conditions of Iraqi patients who are chronic hepatitis virus B or HBV carriers. The study included (111) chronically-viral hepatitis type (b) and (112) hepatitis virus surface antigen type (b) healthy carriers from out of patients. The result of this study proved that a non-significant correlation was observed between cellular immune response (CD4 and CD8) among chronic hepatitis B patients. For CD8+ lymphocytes: there was a highly significant decrease (P |
References |
Boonstra, A., Woltman, A. M., & Janssen, H. L. A. (2008). Immunology of hepatitis B and hepatitis C virus infections. Best Practice and Research: Clinical Gastroenterology, 22(6), 1049-1061. doi:10.1016/j.bpg.2008.11.015 Carinelli, S., Martí, M., Alegret, S., & Pividori, M. I. (2015). Biomarker detection of global infectious diseases based on magnetic particles. New Biotechnology, 32(5), 521-532. doi:10.1016/j.nbt.2015.04.002 Chisari, F. V., Isogawa, M., & Wieland, S. F. (2010). Pathogenesis of hepatitis B virus infection. [Pathogenèse de l'infection par le virus de l'hépatite B] Pathologie Biologie, 58(4), 258-266. doi:10.1016/j.patbio.2009.11.001 Choi, J. (2012). Oxidative stress, endogenous antioxidants, alcohol, and hepatitis C: Pathogenic interactions and therapeutic considerations. Free Radical Biology and Medicine, 52(7), 1135-1150. doi:10.1016/j.freeradbiomed.2012.01.008 Durantel, D., & Zoulim, F. (2016). New antiviral targets for innovative treatment concepts for hepatitis B virus and hepatitis delta virus. Journal of Hepatology, 64(1), S117-S131. doi:10.1016/j.jhep.2016.02.016 European Association for the Study of the Liver, Agarwal, K., Berg, T., Buti, M., Janssen, H. L. A., Papatheodoridis, G., . . . Tacke, F. (2017). EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection. Journal of Hepatology, 67(2), 370-398. doi:10.1016/j.jhep.2017.03.021 Fahey, S., Dempsey, E., & Long, A. (2014). The role of chemokines in acute and chronic hepatitis C infection. Cellular and Molecular Immunology, 11(1), 25-40. doi:10.1038/cmi.2013.37 Froghi, S., Grant, C. R., Tandon, R., Quaglia, A., Davidson, B., & Fuller, B. (2021). New insights on the role of TRP channels in calcium signalling and immunomodulation: Review of pathways and implications for clinical practice. Clinical Reviews in Allergy and Immunology, 60(2), 271-292. doi:10.1007/s12016-020-08824-3 Guidotti, L. G., & Chisari, F. V. (2006). Immunobiology and pathogenesis of viral hepatitis doi:10.1146/annurev.pathol.1.110304.100230 Retrieved from www.scopus.com Humby, S. A. (2017). An Investigation of the Effects of Helminth Worm Infection on the Capacity of HIV Vaccines to Boost Vaccine-Generated Immune Responses, Retrieved from www.scopus.com Isogawa, M., Chung, J., Murata, Y., Kakimi, K., & Chisari, F. V. (2013). CD40 activation rescues antiviral CD8+ T cells from PD-1-mediated exhaustion. PLoS Pathogens, 9(7) doi:10.1371/journal.ppat.1003490 Janssen, H. L. A., Brunetto, M. R., Kim, Y. J., Ferrari, C., Massetto, B., Nguyen, A. -., . . . Gane, E. J. (2018). Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B. Journal of Hepatology, 68(3), 431-440. doi:10.1016/j.jhep.2017.10.027 Khan, A. A., Srivastava, R., Vahed, H., Roy, S., Walia, S. S., Kim, G. J., . . . BenMohamed, L. (2018). Human asymptomatic epitope peptide/ CXCL10-based prime/pull vaccine induces herpes simplex virus-specific gamma interferon-positive CD107+ CD8+ T cells that infiltrate the corneas and trigeminal ganglia of humanized HLA transgenic rabbits and protect against ocular herpes challenge. Journal of Virology, 92(16) doi:10.1128/JVI.00535-18 Khong, H., & Overwijk, W. W. (2016). Adjuvants for peptide-based cancer vaccines. Journal for ImmunoTherapy of Cancer, 4(1) doi:10.1186/s40425-016-0160-y Kleiner, D. E., Chalasani, N. P., Lee, W. M., Fontana, R. J., Bonkovsky, H. L., Watkins, P. B., . . . Hoofnagle, J. H. (2014). Hepatic histological findings in suspected drug-induced liver injury: Systematic evaluation and clinical associations. Hepatology, 59(2), 661-670. doi:10.1002/hep.26709 Knolle, P. A., & Thimme, R. (2014). Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology, 146(5), 1193-1207. doi:10.1053/j.gastro.2013.12.036 Lee, C. K., Han, K. H., Suh, J. H., Cho, Y. S., Won, S. Y., Chon, C. Y., . . . Park, I. S. (2005). HBV-specific CD8+ T cells for sustained HBeAg seroconversion after lamivudine therapy. The Korean Journal of Hepatology, 11(1), 34-42. Retrieved from www.scopus.com Mizukoshi, E., Sidney, J., Livingston, B., Ghany, M., Hoofnagle, J. H., Sette, A., & Rehermann, B. (2004). Cellular immune responses to the hepatitis B virus polymerase. Journal of Immunology, 173(9), 5863-5871. doi:10.4049/jimmunol.173.9.5863 Peng, G., Li, S., Wu, W., Tan, X., Chen, Y., & Chen, Z. (2008). PD-1 upregulation is associated with HBV-specific T cell dysfunction in chronic hepatitis B patients. Molecular Immunology, 45(4), 963-970. doi:10.1016/j.molimm.2007.07.038 Penna, A., Del Prete, G., Cavalli, A., Bertoletti, A., D'Elios, M. M., Sorrentino, R., . . . Ferrari, C. (1997). Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology, 25(4), 1022-1027. doi:10.1002/hep.510250438 Perrella, A., Recioppi, L., & Atripaldi, L. (2006). HBV vaccination with evidence of productive antibodies titer induces CD8+ / CD25+ T cells. Digestive, , 20-25. Retrieved from www.scopus.com Ponte, R., Rancez, M., Figueiredo-Morgado, S., Dutrieux, J., Fabre-Mersseman, V., Charmeteau-de-Muylder, B., . . . Couëdel-Courteille, A. (2017). Acute simian immunodeficiency virus infection triggers early and transient interleukin-7 production in the gut, leading to enhanced local chemokine expression and intestinal immune cell homing. Frontiers in Immunology, 8(MAY) doi:10.3389/fimmu.2017.00588 Puoti, M., Torti, C., Bruno, R., Filice, G., & Carosi, G. (2006). Natural history of chronic hepatitis B in co-infected patients. Journal of Hepatology, 44(SUPPL. 1), S65-S70. doi:10.1016/j.jhep.2005.11.015 Puro, R., & Schneider, R. J. (2007). Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA. Journal of Virology, 81(14), 7351-7362. doi:10.1128/JVI.00554-07 Ramalingam, S. (2015). Study of Seroprevalence of Hepatitis B Virus in Medico Legal Autopsies, Retrieved from www.scopus.com Rehermann, B. (2013). Pathogenesis of chronic viral hepatitis: Differential roles of T cells and NK cells. Nature Medicine, 19(7), 859-868. doi:10.1038/nm.3251 Salpini, R., Colagrossi, L., Bellocchi, M. C., Surdo, M., Becker, C., Alteri, C., . . . Svicher, V. (2015). Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression. Hepatology, 61(3), 823-833. doi:10.1002/hep.27604 Sierra-Davidson, K. (2016). Single-Cell Transcriptional Analysis of Malaria-Specific T Lymphocytes Following Vaccination and Protection in Humans, Retrieved from www.scopus.com Sitia, G., Iannacone, M., Müller, S., Bianchi, M. E., & Guidotti, L. G. (2007). Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. Journal of Leukocyte Biology, 81(1), 100-107. doi:10.1189/jlb.0306173 Spickett, G. (2006). Oxford Handbook of Clinical Immunology and Allergy, Retrieved from www.scopus.com Stanley, W. J. (2018). Activation of islet inflammation by cytokine signalling in pancreatic beta cells: Understanding the role of protein tyrosine phosphatases (doctoral dissertation. Retrieved from www.scopus.com Trépo, C., Chan, H. L. Y., & Lok, A. (2014). Hepatitis B virus infection. The Lancet, 384(9959), 2053-2063. doi:10.1016/S0140-6736(14)60220-8 Wang, L., Wang, K., & Zou, Z. Q. (2015). Crosstalk between innate and adaptive immunity in hepatitis B virus infection. World Journal of Hepatology, 7(30), 2980-2991. doi:10.4254/wjh.v7.i30.2980 Weidt, G., Utermöhlen, O., Heukeshoven, J., Lehmann-Grube, F., & Deppert, W. (1998). Relationship among immunodominance of single CD8+ T cell epitopes, virus load, and kinetics of primary antiviral CTL response. Journal of Immunology, 160(6), 2923-2931. Retrieved from www.scopus.com Wherry, E. J., & Kurachi, M. (2015). Molecular and cellular insights into T cell exhaustion. Nature Reviews Immunology, 15(8), 486-499. doi:10.1038/nri3862 Xu, D., Fu, J., Jin, L., Zhang, H., Zhou, C., Zou, Z., . . . Wang, F. -. (2006). Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. Journal of Immunology, 177(1), 739-747. doi:10.4049/jimmunol.177.1.739 Zhang, Y., Cobleigh, M. A., Lian, J. -., Huang, C. -., Booth, C. J., Bai, X. -., & Robek, M. D. (2011). A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus. Gastroenterology, 141(5), 1897-1906. doi:10.1053/j.gastro.2011.06.051
Zhou, P., Xu, J., Dai, M., Shi, Y., Wu, G., Fang, Y., & Yan, X. (2018). The immunosuppressive effects of CD4+CD25+ regulatory T cells on dendritic cells in patients with chronic hepatitis B. Journal of Viral Hepatitis, 25(6), 733-741. doi:10.1111/jvh.12863 Zhu, A. X., Finn, R. S., Edeline, J., Cattan, S., Ogasawara, S., Palmer, D., . . . KEYNOTE-224 investigators. (2018). Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): A non-randomised, open-label phase 2 trial. The Lancet Oncology, 19(7), 940-952. doi:10.1016/S1470-2045(18)30351-6 |
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