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Type :thesis
Subject :QD Chemistry
Main Author :Wong, Susana Siew Tin
Title :Preparation, characterisation and effectiveness of nanocomposites based on Go-Fe3O4 as nanocarriers for insecticide compounds
Place of Production :Tanjong Malim
Publisher :Fakulti Sains dan Matematik
Year of Publication :2022
Corporate Name :Universiti Pendidikan Sultan Idris
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Abstract : Universiti Pendidikan Sultan Idris
This research aimed to prepare, characterise and study the effectiveness of two magnetic graphene oxide-based nanocomposites, namely gellan gum-graphene oxide (GG-GO-Fe3O4) and pectin-graphene oxide (PEC-GO-Fe3O4) as nanocarriers for permethrin and cinnamaldehyde insecticide compounds. This research is divided into three parts, namely preparation, characterisation and effectiveness studies. Nanocomposites with amorphous structure were successfully produced based on the existence of conjugation mechanism between GG and PEC with iron oxide at wavenumber peak 650 cm-1. Results from thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) have shown that the nanocomposites loaded with insecticides are thermally stable. Performance study of nanocomposites loaded with insecticides towards Aedes aegypti larvae was analysed through Abbott’s and Probit’s formula via in vitro at different pH using ultraviolet-visible (UV-Vis) spectrometer. The encapsulation of insecticide to nanocarriers was successfully carried out based on the change in intensity and wavenumber of absorption bands from Fourier Transform Infrared Spectrometer (FTIR) analysis and size increment of nanocarriers in the range of 18.2 to 70.1%. The formulated nanocarriers have successfully prolonged the release duration of permethrin and cinnamaldehyde by 15 and 24 hours, respectively. The release profiles of insecticide compounds were best fitted by Korsemeyer-Peppas kinetic model. Formulation of GG-GO-Fe3O4 nanocarrier loaded with cinnamaldehyde was found as the most effective formulation to control A. aegypti larvae. In conclusion, both nanocarriers studied have shown outstanding performance in loading and releasing permethrin and cinnamaldehyde in larvicide formulations. In implication, the application of both environmental friendly nanocarriers in larvicide formulations could reduce mosquito borne diseases and sustain the environment.

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