The objectives of this study are to synthesize novel chitosan-hydroxyapatite composites doped with strontium, magnesium and zinc via in situ co-precipitation method, to investigate the bioactivity, cytotoxicity and antimicrobial properties of the materials. Physicochemical properties of the products obtained were analysed by X-ray powder diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential thermal analysis (DTA), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). The calcium release from the samples in simulated body fluid (SBF) were measured using atomic absorption spectroscopy (AAS). The synthesized composite materials were subjected to bioactivity studies in SBF. In vitro cytotoxicity studies were performed on the novel composite materials obtained. Antimicrobial activity investigations against E. coli were carried out on all the composite samples. Characterization of the .....

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