This study aimed to investigate the association of polymorphisms of Interleukin-4 (IL- 4) and Interleukin-6 (IL-6) genes to the susceptibility and severity of type-2 diabetes mellitus (T2DM) and to evaluate the serum levels of these interleukins in patients with T2DM. A number of 90 individuals from Wasit province, Iraq inclusive of 64 patients with T2DM and 26 healthy individuals with normal fasting blood sugar as a control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of IL-4 and IL-6 in sera from patients with T2DM. The allele-specific polymerase chain reaction (PCR) technique was used to investigate the polymorphism of the interleukins: IL4 -590C/T, (rs2243250) and IL6 -174G/C, (rs1800795) genes polymorphisms. Results of this study showed that IL-4 concentrations had a non-significant difference (p = >0.052) between patients with T2DM (154.48 pg/ml ± 7.00) with the control group (151.49 pg/ml ± 6.21). Patients with T2DM revealed an ele.....

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