The objectives of this study were to review and perform a computational study on previously reported flavonoids as tubulin inhibitors and to design and synthesize new bioavailable flavonoids as anticancer agents targeting tubulin. The Molecular Operating Environment (MOE 2019.0102) software was used for molecular docking (MD) and QSAR studies of reported and newly designed flavonoids. The ADMET and bioavailability studies were performed using the pkCSM online server. New flavonoids were successfully prepared from commercially available hydroxy benzaldehydes and acetophenones using multistep chemical synthesis including alkylation, Claisen Schmidt condensation and cyclization reactions. All intermediates and new flavonoids were purified using silica gel column chromatography, and their chemical structures were confirmed using NMR and LC-MS spectral analysis. The results of this study illustrated that only 14 flavonoids have reported IC50 as tubulin polymerization inhibitors and the MD s.....

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